Gilles Gasser,* Ingo Ott,* and Nils Metzler-Nolte* Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland, Institute of Pharmaceutical Chemistry, Technische Universit€ at Braunschweig, Beethovenstrasse 55, 38106 Braunschweig, Germany, and Chair of Inorganic Chemistry I, Bioinorganic Chemistry, Faculty of Chemistry and Biochemistry, Ruhr Univ...

A molecular orbital study of the reaction path for the methyl migration reaction in CH3Mn(C0)5, the "carbonyl insertion reaction", is the starting point for a general analysis of organometallic migration reactions. The reaction path contains a five-coordinate intermediate and a transition state close in energy to the intermediate. Among the questions studied are the stereochemical course of the...

The regio- and stereoselective ring-opening of a 2-(2'-oxiranyl)-1,2,3,6-tetrahydropyridine using organometallic reagents is reported. The choice of the organometallic reagent determines the formation of either 2-[(R)-1-hydroxyalkyl]- or 2-[(S)-2-hydroxy-1-alkyl]-1,2,3,6-tetrahydropyridines. The formation of 2-[(S)-2-hydroxy-1-alkyl]-1,2,3,6-tetrahydropyridines is a rare example of epoxide ring...

During these last years, cyclodextrins have contributed greatly to the development of catalytic processes in water. These cyclic oligosaccharides composed of 6(), 7() or 8() glucopyranose units improve the mass transfer in aqueous-organic two-phase systems and are useful compounds to design new catalysts. Thus, chemically modified cyclodextrins can be used to: (i) increase significantly the ...