Organometallic complexes with thiopyrone-based ligands have shown promising cytotoxic activity in vitro. To investigate the impact of the ligand backbone modification of these biologically active compounds and enhance the solubility in aqueous solution, the (thio)pyrone scaffold was modified via Suzuki-Miyaura coupling reaction and converted into corresponding organometallic Ru(ii) and Rh(iii) ...

Recently, solid-phase synthesis has been recognized as an important methodology for combinatorial chemistry or automated synthesis directed at drug discovery. Various synthetic methodologies have been applied to solid-phase synthesis, although it appears that organometallic chemistry in this area is still being explored. In solution-phase chemistry, organometallic reagents have been utilized fo...

This chapter will focus on the formation processes and fate of the more common methylated metals and metalloids in the aquatic environment, focusing on both the ocean and freshwa‐ ter ecosystems. In addition to the formation of the methylated compounds, the biotic and abiotic degradation of these compounds in the natural environment will also be discussed. The formation pathways and the microbe...

During these last years, cyclodextrins have contributed greatly to the development of catalytic processes in water. These cyclic oligosaccharides composed of 6(), 7() or 8() glucopyranose units improve the mass transfer in aqueous-organic two-phase systems and are useful compounds to design new catalysts. Thus, chemically modified cyclodextrins can be used to: (i) increase significantly the ...

In a previous work we have demonstrated the antimicrobial activity of ferrocenyl or phenyl derivatives of diphenyl butene series. This finding has opened a new area of applications of organometallic compounds. In order to improve these activities, we have synthesized new organic and organometallic diaryl butene compounds with different lengths of their amino chains. These new compounds, and als...

This paper presents the synthesis, the structural determination and the sensing capabilities toward Volatile Organic Compounds (VOCs) of a new class of fluorescent indolizine-cyclodextrin sensors. Two different pathways, both involving bipyridinium ylides and 6-amino-b-cyclodextrin, have been used to carry out the synthesis of these sensors. The macrocycle structures were dominantly established...

Sediment samples were collected in the Gulf of Gdańsk, and the Vistula and Szczecin Lagoons-all located in the coastal zone of the Southern Baltic Sea-just after the total ban on using harmful organotins in antifouling paints on ships came into force, to assess their butyltin and phenyltin contamination extent. Altogether, 26 sampling stations were chosen to account for different potential expo...

Since the seminal work of Butlerov (1863) 1a and Grignard (1900), the addition of preformed organometallic reagents to carbonyl compounds has played a central role in chemical synthesis. While this technology has opened vast volumes of chemical space, the basicity of most organometallic reagents mandates “protection” of acidic substructures, including the ubiquitous hydroxyl group. For the synt...

Arylalkylamines are of interest as building blocks for the synthesis of biologically active compounds and as chiral ligands or chiral auxiliaries in stereoselective syntheses [1]. Their stereoselective synthesis has been achieved by enantioselective reduction of ketimines using chiral reagents [2], as for example Corey’s oxaborolidines [3], or proline-derived triacyloxyborohydrides [4]. Particu...