Potent cannabinoid CB1 receptor ligands include anandamide [N-(2-hydroxyethyl)arachidonamide], Delta9-tetrahydrocannabinol, and 3H-CP 55,940 at the agonist site and selected organophosphorus esters (including some pesticides) and organosulfur compounds at a proposed closely coupled "nucleophilic" site. This study considers the toxicological and structural features of alkylfluorophosphonates, be...

2-phosphonobutane-1,2,4-tricarboxylic acid is(pbtc) a member of phosphonate family, and used as corrosion and scale inhibitor in cooling water systems. phosphonocarboxylates as a member of organophosphorus compounds have c-p and p-o bonds in their structures. pbtc is mainly used as carbonate scale inhibitor (caco3), sulphate scale inhibitor (caso4), corrosion inhibitor of low alloyed steel, eff...

background: prolonged inhibition of acetylcholine esterase may lead to the intermediate syndrome. neuromuscular junction (nmj) dysfunction has been shown with repetitive nerve stimulation (rns). subclinical nmj dysfunction may also occur. we aimed to examine the nmj function following acute organophosphorus (op) poisoning by using exercise modified slow rns. methods: a cohort study was conducte...

The use of organophosphorus pesticides results in toxicity risk to non-target organisms. Organophosphorus compounds share a common mode of action, exerting their toxic effects primarily via acetylcholinesterase (AChE) inhibition. Consequently, acetylcholine accumulates in the synaptic clefts of muscles and nerves, leading to overstimulation of cholinergic receptors. Acute cholinergic crisis imm...

Organophosphorus insecticides elicit toxicity by inhibiting acetylcholinesterase. Young animals are generally more sensitive than adults to these toxicants. A number of studies reported that some organophosphorus agents also bind directly to muscarinic receptors, in particular the m(2) subtype, in tissues from adult rats. As both the density and agonist affinity states of cardiac muscarinic rec...

Presently, organophosphorus pesticides (OPs) have largely replaced organochlorine compounds in the agricultural activities. Total turnover of OPs has increased around the world. Their residues have been detected in ground and drinking waters (Barceló, 1993), natural surface waters (Hernández et al., 1996), marine organisms (Barceló et al., 1990) and food products (Gunderson, 1995; Dejonkeheer e...

We report a biosensor based on organophosphorus hydrolase (OPH) multilayer modified microcantilever (MCL) for detection of organophosphorus compounds (OPs). The assay is based on substrate-dependent bending of the OPH functionalized MCLs. The cantilever bending amplitude at equilibrium was a function of the concentration of paraoxon with the dynamic range extending from 10(-7) to 10(-3)M. The l...

The use of the oxime P2S as intravenous therapy for organophosphorus anticholinesterase poisoning is well known. In emergency situations this route of administration may prove impractical due to severe symptoms of anticholinesterase poisoning and therefore the intramuscular route is to be preferred. The absolute intramuscular dose of P2S per man, recommended as necessary for adequate therapy of...

A simple and rapid method is described for the estimation of some organophosphorus insecticides in the serum of occupationally exposed persons. The compounds are extracted with a mixture of acetone and diethyl ether (1:1 v/v) in acidic medium and the extraction residue is analyzed by gas chromatography with nitrogen phosphorus detection method. Linearity was acceptable over concentrations from ...