Standard treatment of poisoning by organophosphorus anticholinesterases uses atropine to reduce the muscarinic effects of acetylcholine accumulation and oximes to reactivate acetylcholinesterase (the effectiveness of which depends on the specific anticholinesterase), but does not directly address the nicotinic effects of poisoning. Bispyridinium molecules which act as noncompetitive antagonists...

daily, organophosphorus compounds (ops) in human life, has found wide applications. although ops have biodegradability potential, they induce clinical problems in humans and other organism. different methods are used to detoxify these compounds. in the meantime, biodegradation is preferred as a compatible way to the environment since it produces less toxic compounds. enzymes capable to degrade ...

Bacteria were isolated that could utilize representatives of the following ionic phosphorus-containing breakdown products of organophosphorus pesticides as sole phosphorus sources: dialkyl phosphates, dialkyl phosphorothioates, dialkyl phosphorodithioates, alkyl arylphosphonates, alkyl arylphosphonothioates, and alkyl alkylphosphonates. Utilization of each organophosphorus compound, which was c...

1. The delayed neurotoxic effects of some organophosphorus compounds are associated with phosphorylation of the active site of a nervous-tissue enzyme capable of hydrolysing phenyl phenylacetate. 2. Neurotoxic organophosphorus compounds and some carbamates and sulphonyl fluorides progressively inhibit the enzyme, attaching a substituent covalently at the active site. 3. Prolonged inhibition of ...

1 Associate Professor, Department of Biochemistry, R.C.S.M. Govt. Medical College, Kolhapur 2 Technician, Department of Biochemistry, Govt. Medical College, Miraj 3 Ph D student, Department of Biochemistry, Govt. Medical College, Miraj Corresponding Author Dr Karan Ningappa Pujari Associate professor, Department of Biochemistry, R.C.S.M. Govt. Medical College, Kolhapur (Maharashtra, India). Ema...

Enzymes that are capable of degrading neurotoxic organophosphorus compounds are of increasing interest because of the lack of efficient and clean methods for their removal. Recently, a novel organophosphorus hydrolase belonging to the metallo-β-lactamase superfamily was identified and isolated from the mesophilic bacterium Pseudomonas pseudoalcaligenes. This enzyme, named OPHC2, is endowed with...

Various approaches leading to mono-, diand poly-functionalized phosphonates as well as phosphoryl heterocycles were reported for the systematic study of relationship between chemical structure and biological activities of this most important class of organophosphorus compounds. Introduction Functionalization of phosphonic acid molecules opens enoi-nious possibilities of structural variation of ...

From literature data on partition coefficients and in some cases solubilities in nonaqueous solvents we have been able to determine Abraham descriptors for several series of organophosphorus compounds including the dialkyl- and diaryl-phosphates (dialkylphosphoric acids), trialkyl- and triphenyl-phosphates, dialkylphosphinic acids and diphenylphosphinic acid, trialkyl- and triaryl-phosphine oxi...

Seventy five cases of attempted suicide were studied over a period of one and half years (from January 1996 to June 1997). The findings revealed that 85.4% cases were in the age group 15-54 years. Females (53.4%) and unmarried (52%) attempted suicide more often. House wives (32%) and students (28%) were the two commonest occupational categories involved. Organophosphorus compounds were consumed...