Mariana Siviero, Manoel Jacobsen Teixeira, José Tadeu Tesseroli de Siqueira, Sı́lvia Regina Dowgan Tesseroli de Siqueira I Orofacial Pain Team, Faculdade de Medicina da Universidade de Sao Paulo, Brazil. II Neurology Department, Faculdade de Medicina da Universidade de Sao Paulo, Brazil. III Head of the Orofacial Pain Team, Dentistry Division, Faculdade de Medicina da Universidade de Sao Paulo, ...

Orofacial pain is a prevalent symptom in modern society. Some musculoskeletal orofacial pain is caused by temporomandibular disorders (TMDs). This condition has a multi-factorial etiology, including emotional factors and alteration of the masticator muscle and temporomandibular joints (TMJs). TMJ inflammation is considered to be a cause of pain in patients with TMD. Extracellular proteolytic en...

Pain in the orofacial region is the most common reason for patients to visit a dental clinic. Tooth and/or its supporting structures are often source of pain. Pain originating from pulp dentine complex and/or periodontal structures presents with variable clinical characteristics and can be accurately diagnosed and treated. However, clinician often encounters situation when odontogenic causes of...

One of the most challenging clinical issues the dentist confronts is the patient with persistent orofacial pain without obvious proximate physical cause. Patients with persistent pain often seek consultation from many clinicians and undergo multiple unnecessary procedures before receiving a correct diagnosis and appropriate treatment. Clinicians unfamiliar with neuropathic pain may become frust...

Background & Aim: Eugenia caryophyllata well known as Clove is a tree from Myrtaceae family that several parts of this plant traditionally used in dental care as an analgesic. This study aimed to assess the chemical composition, anti-inflammatory and anti-nociceptive activities of the essential oil extracted from Clove buds. Experimental: The essential oil of Clove buds (EOC) was extr...

Background & Aim: Eugenia caryophyllata well known as Clove is a tree from Myrtaceae family that several parts of this plant traditionally used in dental care as an analgesic. This study aimed to assess the chemical composition, anti-inflammatory and anti-nociceptive activities of the essential oil extracted from Clove buds. Experimental: The essential oil of Clove buds (EOC) was extr...

OBJECTIVE To present a case of complex regional pain syndrome (CRPS) type II with sympathetic dysfunction and trophic changes in the orofacial region, which was partially responsive to intravenous ketamine. PATIENT The patient was a 68-year-old man who suffered from inveterate pain with trophic changes of the right face and tongue and vasomotor dysfunction on the right side of the face after ...

OBJECTIVES Crocin, a constituent of saffron and yellow gardenia, possesses anti-nociceptive effects. In the present study, we investigated the effects of intra-fourth ventricle injection of crocin in a rat model of orofacial pain. The contribution of opioid system was assessed using intra-fourth ventricle injection of naloxone, an opioid receptor antagonist. MATERIALS AND METHODS A guide cann...