Titanium (Ti) and its alloys are attracting special attention in the field of dentistry orthopedic bioengineering because their mechanical adaptability biological compatibility with natural bone. The dental implant is subjected to masticatory forces oral environment transfers these surrounding bone tissue. Therefore, by simulating behavior implants tissue we can assess effects on growth quite a...

Magnesium alloys as degradable implant materials in orthopaedic research received a lot of interest in recent years (Witte et al., 2007a; Xu et al., 2008; Zhang et al., 2010). The application of resorbable implant material avoids an implant removal surgery and therewith helps to diminish the costs and the burden for the patient. In comparison to other degradable implant materials like polymers,...

Previous studies based on small sample sizes have reported the application of the Zero-P implant (Zero-P, Synthes GmbH, Switzerland) in single anterior cervical discectomy and fusion (ACDF) surgery with excellent outcomes. However, the safety and effectiveness of two-level ACDF with Zero-P implant still remains controversial. A retrospective study was conducted to compare the clinical outcomes ...

The functional success of a biomedical implant critically depends on its stable bonding with the host tissue. Aseptic implant loosening accounts for more than half of all joint replacement failures. Various materials, including metals and plastic, confer mechanical integrity to the device, but often these materials are not suitable for direct integration with the host tissue, which leads to imp...

Bone infections of patients with joint replacement by endoprosthesis (so called "periprosthetic joint infection") pose a severe problem in the field of orthopedic surgery. The diagnosis is often difficult, and treatment is, in most cases, complicated and prolonged. Patients often require an implant exchange surgery, as the persistent infection and the accompanying inflammation lead to tissue da...

Many surgical procedures use metal implants in bone. The clinical results depend on the strength of the bone holding these implants. Our objective was to show that a drug released from the implant surface can improve parameters reflecting the quality or amount of this bone. Sixteen patients received paired dental titanium implants in the maxilla, in a randomized, double-blinded fashion. One imp...

Radial head implant arthroplasty is a consideration for the treatment of comminuted, unreconstructable fractures of the radial head. Many prosthetic designs exist and can be unipolar or bipolar, each of which can be cemented or noncemented. For most unipolar designs, a prosthetic stem is first implanted into the proximal radius. The prosthetic radial head is then impacted onto a morse taper on ...

Magnesium and its alloys are being paid much attention recently as temporary implants, such as orthopedic implants and cardiovascular stents. However, the rapid degradation of them in physiological environment is a major obstacle preventing their wide applications to date, which will result in rapid mechanical integrity loss or even collapse of magnesium-based implants before injured tissues he...

Biologic response to orthopedic implants debris is central to clinical performance. Eventual implant loosening due to aseptic osteolysis has been attributed to local inflammatory responses to wear and corrosion products that are produced by articulating implant interfaces. The response to implant debris is dominated by local immune activation, e.g. macrophages. Immune reactivity has been shown ...

The fixation of an orthopedic implant depends strongly upon its initial stability. Peri-implant bone may resorb shortly after the surgery. This resorption is directly followed by new bone formation and implants fixation strengthening, the so-called secondary fixation. If the initial stability is not reached, the resorption continues and the implant fixation weakens, which leads to implant loose...