New strategies involving bone-targeting titanium (Ti) implant-bone interface are required to enhance bone regeneration and osseointegration for orthopedic and dental implants, especially in osteoporotic subjects. In this study, a new dual-controlled, local, bone-targeting delivery system was successfully constructed by loading tetracycline-grafted simvastatin (SV)-loaded polymeric micelles in t...

DEVELOPMENT AND APPLICATION OF BIOMIMETIC ELECTROSPUN NANOFIBERS INTOTAL JOINT REPLACEMENTbyWEI SONGMay 2014Advisor: Dr. Weiping RenMajor: Biomedical EngineeringDegree: Doctor of Philosophy Failure of osseointegration (direct anchorage of an implant by bone formation at the bone‐implant surface) and implant infection (such as that caused by Staphylococcus aur...

BACKGROUND Successful dental and orthopedic implants require the establishment of an intimate association with bone tissue; however, the mechanistic explanation of how biological systems accomplish osseointegration is still incomplete. We sought to identify critical gene networks involved in osseointegration by exploring the implant failure model under vitamin D deficiency. METHODOLOGY Adult ...

Implant failure due to poor integration of the implant with the surrounding biomaterial is a common problem in various orthopedic and orthodontic surgeries. Implant fixation mostly depends upon the implant surface topography. Micron to nanosize circular-shaped groove architecture with adequate surface roughness can enhance the mechanical interlock and osseointegration of an implant with the hos...

Titanium (Ti) and its alloys have been extensively used as implant materials in orthopedic applications. Nevertheless, implants may fail due to a lack of osseointegration and/or infection. The aim of this in vitro study was to endow an implant surface with favorable biological properties by the dual modification of surface chemistry and nanostructured topography. The application of a nanostruct...

BACKGROUND Surface functionalization of orthopedic implants with pharmaceutically active agents is a modern approach to enhance osseointegration in systemically altered bone. A local release of strontium, a verified bone building therapeutic agent, at the fracture site would diminish side effects, which could occur otherwise by oral administration. Strontium surface functionalization of special...

BACKGROUND Postoperative infection associated with implants remains a serious complication in orthopedic surgery. Several biomaterial surface treatments have been proposed as a means of reducing the incidence of implant-associated infections. In this study, a clinical trial was performed using an iodine-supported titanium that suppresses the microbial activities. METHODS A total of 222 patien...

3D printed porous titanium (Ti) holds enormous potential for load-bearing orthopedic applications. Although the 3D printing technique has good control over the macro-sturctures of porous Ti, the surface properties that affect tissue response are beyond its control, adding the need for tailored surface treatment to improve its osseointegration capacity. Here, the one step microarc oxidation (MAO...

Prolonged inflammation induced by orthopedic metallic implants can critically affect the success rates, which even lead to aseptic loosening and consequent implant failure. In case of adverse clinical conditions involving osteoporosis, trauma corrosion-wear in peri-implant region, reactive oxygen species (ROS) activity is enhanced leads increased oxidative stress. Metallic materials (such as ti...

Porous titanium is proposed to be an effective orthopedic implant with a lower elastic modulus and supports osseointegration during implantation. To produce porous titanium, powder metallurgy (PM) assisted space-holder used in this study. Pure as the starting material, salt (NaCl) space-holder. Argon-atmospheric sintering arc plasma (APS) methods are applied for process. NaCl content was varied...