In order to decrease the peri-implant bone loss during the life-time of the implant, oral use of anti-osteoporosis drugs (like bisphosphonates) has been suggested. In this study, bone remodeling parameters identified from clinical trials of alendronate were used to simulate the effect of those drugs used after total hip arthroplasty on the peri-implant bone density. Results of the simulation sh...

The application of implants for dental and orthopedic surgery has increased rapidly within the past few decades. In craniomaxillofacial surgery, different implant systems have been applied, for example, for dental and bone replacement or osteosynthesis plates and screws. These implants may be made of pure titanium or a titanium alloy, usually titanium-aluminumvanadium (Ti-6Al-4V). The surface c...

background implant removal is a common procedure in orthopedic surgery which can be associated with many complications such as scar formation, hematoma, nerve injury, infection, and refracture. indications for orthopedic implant removal have declined in recent years. most studies have considered orthopedic hardware removal as an unnecessary procedure in the absence of severe complications such ...

The ability of an orthopedic implant to integrate successfully with the surrounding bone tissue is imperative for optimal patient outcomes. Here, recent advances and future prospects diamond-based coatings conventional osteo-implant materials (primarily titanium) are explored. these diamond enhance integration into existing bone, improved mechanical properties, facilitate surface chemical funct...

Orthopedic implants fail due to various reasons such as extensive bacterial colonization, poor osseointegration, extensive inflammation and osteolysis due to wear debris. In order to reduce orthopedic implant failures, the main objective of this study was to create a biomimetic bone tissue engineering material based on the self assembling properties of rosette nanotubes (RNTs), the osteoconduct...

Current titanium-based implants are often anodized in sulfuric acid (H(2)SO(4)) for color coding purposes. However, a crucial parameter in selecting the material for an orthopedic implant is the degree to which it will integrate into the surrounding bone. Loosening at the bone-implant interface can cause catastrophic failure when motion occurs between the implant and the surrounding bone. Recen...

Particles generated from orthopedic implants through years of wear play an essential role in the aseptic loosening of a prosthesis. We have investigated the biocompatibility of these orthopedic particles on different osteoblast-like cells representative of different stages of osteoblast maturation. We found the particles induced a caspase-dependent apoptosis of osteoblasts, with less mature ost...