Titanium (Ti) and titanium alloy have been widely used in orthopedics. However, the successful application of implants is mainly limited due to implant-associated infections. The implant surface contributes osseointegration, but also has risk accelerating growth bacterial colonies, surfaces infected with bacteria easily form biofilms that are resistant antibiotics. Biofilm-related infections a ...

Despite the success in returning people to health saving mobility and high quality of life, the over 1 million total joint replacements implanted in the US each year are expected to eventually fail after approximately 15-25 years of use, due to slow progressive subtle inflammation to implant debris compromising the bone implant interface. This local inflammatory pseudo disease state is primaril...

Nowadays total joint replacements are widely used in the world, so in average 800,000 joint surgeries are done yearly only in Europe and North America. However implant loosening is and remains as the major issue of all implant failures and therefore causes revision surgery procedures. Studies and experiments have identified poor fixation of implants most likely is the main cause of long term im...

Awareness of rare etiologies for implant failure is becoming increasingly important. In addition to the overall increase in joint arthroplasties, revision surgeries are projected to increase dramatically in the coming years, with volume increasing up to seven-fold between 2005 and 2030. The literature regarding the relationship between metal allergy and implant failure is controversial. It has ...

Fast and reliable methods for predicting and monitoring in-vivo bone strength are of great importance for hip joint replacement. To avoid adaptive remodeling with cortical thinning and increased porosity of the bone due to stress shielding, in a preoperative planning process the optimal implant design, size, and position has to be determined. This process involves interactive implant positionin...