Chemotherapy resistance has become the main obstacle for the effective treatment of human cancers. Long non-coding RNA urothelial cancer associated 1 (UCA1) is generally regarded as an oncogene in some cancers. However, the function and molecular mechanism of UCA1 implicated in cisplatin (CDDP) chemoresistance of oral squamous cell carcinoma (OSCC) is still not fully established. UCA1 expressio...

Objectives: DNA methylation, which is the most frequently observed epigenetic change, very important because it seen in early stages of cancer. Abnormal methylation promoter regions and silencing tumor suppressor genes play a key role development oral squamous cell carcinoma (OSCC). In our study*, was aimed to identify validate new biomarker candidates via epigenomics/transcriptomics approaches...

CT: computerized tomography OSCC: oral squamous cell carcinoma RMT: retromolar trigone INTRODUCTION Oral squamous cell carcinoma (OSCC) has historically been treated with surgery or radiation with or without chemotherapy, all of which lead to significant posttreatment morbidity. Topical imiquimod cream has been approved by the Food and Drug Administration for treatment of nonhyperkeratotic acti...

conclusions according to the low prevalence of hcmv in oscc, it seems that this virus plays a minor role in this kind of cancer at least in southeast of iran. more comprehensive studies are needed to investigate the oncomodulatory effect of this virus on oscc. results the mean age of the patients (66.7% female and 33.3% male) was 58.6 years. only three cases (6.3%) of the grade i, oscc biopsies...

The etiology of oral squamous cell carcinoma (OSCC) is complex and involves many factors. The most clearly defined risk factors are smoking and alcohol, which substantially increase the risk of oral SCC. However, despite this clear association, a substantial proportion of patients develop OSCC without exposure to them, emphasizing the role of other risk factors such as genetic susceptibility an...

The aim of this study was to analyze proliferative verrucous leukoplakia (PVL) and oral squamous cell carcinoma (OSCC) for the possible presence of Epstein-Barr virus (EBV). We studied three groups: Sub-Group 1 was composed of 10 patients with PVL, (6 of whom had developed OSCC); Sub-Group 2 comprised 5 patients with OSCC but no preceding PVL; and Sub-Group 3 were 5 controls with clinically nor...

Due to a high risk and tendency of OPMDs towards OSCC, its early detection is essential for better survival rate. Several molecular markers are available diagnosis prognostic assessments OPMDs, also evaluating aggressiveness OSCC. Objectives: To assess the immuno-histochemical expression Cyclin D1 in normal healthy oral mucosa. has significant role cell cycle control strongly linked with metast...

Dysregulation of long non-coding RNAs (lncRNAs) plays a critical role in tumor progression. LncRNA antisense non-coding RNA in the INK4 locus (ANRIL) has been reported to promote tumor progression in numerous cancers. However, its expression and function in oral squamous cell carcinoma (OSCC) remain largely unclear. Herein, we investigated the expression and clinical significance of lncRNA ANRI...

BACKGROUND BCL-2 and BAX are important in the regulation of apoptosis. There have been reports of loss of BCL-2 in basal cells of oral epithelial dysplasia (OED) and in oral squamous cell carcinoma (OSCC), and suppression of BAX in poorly differentiated OSCC. AIM To investigate whether loss of BCL-2 in OED and OSCC, and of BAX in poorly differentiated OSCC could be attributed to BCL-2 and BAX...