Using clinical, morphological, genetic, and biochemical criteria, we studied ten white and North African families with hereditary elliptocytosis (HE). In four families, elliptocytic individuals displayed a highly significant reduction of band 4.1, which was recorded using two electrophoretic procedures. The 4.1a/4.1b ratio was also significantly reduced, as is usually observed in suspensions en...

Osmotic laxatives produce the best results. Fiber and behavior modification may have a role. Increased fiber and behavior modification are the most often recommended first steps in managing chronic functional constipation (CFC) in children, but only limited evidence supports this approach. For pharmacologic management, the best evidence supports osmotic laxatives.

A family of mixed Indian-Portuguese ancestry is reported in which there is a hereditary persistence of foetal haemoglobin and beta-chain thalassaemia. The propositus, a 17-year-old boy, was found to have a mild haemolytic anaemia characterized by slight splenomegaly, microcytosis, numerous target cells, decreased osmotic fragility, a very high level of foetal haemoglobin (75%), and normal haemo...

Intravascular hemolysis is one of the most emphasized mechanisms for destruction of erythrocytes during and after physical activity. Exercise-induced oxidative stress has been proposed among the different factors for explaining exercise-induced hemolysis. The validity of oxidative stress following exhaustive cycling exercise on erythrocyte damage was investigated in sedentary and trained subjec...

Recent macro developments in the euro area have highlighted the interactions between fiscal policy, sovereign debt, and financial fragility. We take a structural macroeconomic model with frictions in the financial intermediation process, in line with recent research, but introduce asset choice and sovereign debt holdings in the portfolio of banks. Using this model, we emphasize a new crowding-o...

Osmotic swelling is a common feature of many cataracts. Sugar cataracts and hereditary mouse cataracts are two types in which osmotic changes play a prominent role. In sugar cataracts, the initial swelling brought about by polyol accumuation leads to an imbalance in the pump-leak equilibrium. The pump mechanism becomes unable to keep pace with the leaky membranes. The marked increases in Na and...

Chlorpromazine is a widely used phenothiazine tranquilizer known to alter the shape of normal erythrocytes and their osmotic fragility. In order to understand the nature of the interactions chlorpromazine.HCl (CPZ.HCl) was made to interact with phospholipid bilayers formed by dimyristoylphosphatidylethanolamine (DMPE) and dimyristoylphosphatidylcholine (DMPC). This study was carried out by X-ra...

By ,J. C. SELW YN, M.I). (CANTAB.) AND .J. V. 11 cIE, MI)., M.ILC.P. (LoND.) T HE INCUBATION at 37 C. of sterile defibrimmated blood from cases of hereditary spherocyt.osis result.s iii a more rapid immcrease in osmotic fragility of the m’ed (.ellsm2. 22 amid a more rapid rate of autohemolysis3 ‘ thani normal. The cause of these unusually rapid changes lies in the m’ed (‘ells anm(l nmot mm the ...

During several weeks riboflavin supplementation of lactating African women, which reduced their mean activation coefficient of erythrocyte glutathione reductase (EGRAC) from 1.65 to 1.21 and initiated an improvement in clinical deficiency signs, measurements were made of physiological functions which may be connected with riboflavin status. No specific response to the supplement could be detect...

In this study, the effects of prolonged storage on several biophysical properties of red blood cells (RBCs) were investigated. Single cell deformability was used as an important criterion in determining subgroups of RBCs evolved during storage lesion. A deformability-based microfluidic cell sorting technology was applied, which demonstrates the ability to enrich and separate the less deformable...