OBJECTIVE To compare the phase angle of patients with osteogenesis imperfecta treated at a tertiary university hospital with patients in a control group of healthy children, and to assess the nutritional status of these patients through the body mass index proposed by the World Health Organization. METHODS Cross-sectional study carried out in a university hospital that included seven patients...

Morphological and immunohistochemical effect of cerium dioxide nanoparticles on reparative osteogenesis the jaw bonesErnest Bazikyan, Andrey Chunikhin, Grigory Volozhin, Knarik Abraamyan, Vladimir Ivanov, Mariya S. Zudina

1 Patients with syndromic craniosynostosis display considerable impairment of skull growth and often require cranial expansion to prevent the development of intracranial hypertension within the first year of life. However, the best approach for cranial expansion in this setting remains controversial. Although fronto-orbital advancement (FOA) was a typical option,1 this procedure is plagued by h...

Osteoporosis is an age-related progressive bone disease. Trp53 (p53) is not only a famous senescence marker but also a transcription regulator which played a critical role in osteogenesis. However, how p53 contributes to the bone mass loss in age-related osteoporosis is still unclear. Here, we found that bone mass and osteogenic differentiation capacity of mesenchymal stem cells (MSCs) is signi...

Ectomesenchyme, a derivative of the embryonic neural crest, forms the membrane bones of the mandibular skeleton, but will only do so after undergoing an inductive interaction with mandibular epithelium. Previously, non-mandibular epithelia have been shown to act as effective substitutes for the mandibular epithelium in this interaction. The role of epithelial viability was examined by enzymatic...

BACKGROUND AND PURPOSE Distraction osteogenesis may be used for the treatment of brachymetatarsia. However, few reports have been published on first metatarsal lengthening by this method. We evaluated the complications of distraction osteogenesis for first brachymetatarsia and here we provide a solution. PATIENTS AND METHODS 16 patients (27 feet) underwent distraction osteogenesis for first b...

Distraction osteogenesis is widely used in treating deformities, defects, and fractures of both long bones and craniofacial bones. Demands for acceleration of bone consolidation are increased in distraction osteogenesis. Nerve growth factor (NGF) can enhance innervation and bone regeneration in a fracture model and stimulate differentiation of osteoblastic cells. In this study, we tested the ab...

Most patients with dominantly inherited osteogenesis imperfecta have blue sclerae and relatively mild symptoms. However, in a small group of families the patients have normal sclerae and this disorder has been classified as Type 4 osteogenesis imperfecta. This paper reports the clinical and radiographical features of 48 patients from 16 families with Type 4 osteogenesis imperfecta and compares ...

Mesenchymal stem cells (MSCs) are nonhematopoietic stromal cells that can differentiate into multiple mesodermal lineages including adipocytes, osteoblasts, chondrocytes and myocytes. Adult stem cell differentiation is controlled by activation of lineagespecific transcription factors, including peroxisome proliferator-activated receptor γ (PPARγ) and Runx2, two key transcription factors that go...

The importance of mesenchymal stem cells (MSC) for bone regeneration is growing. Among MSC the bone marrow-derived stem cells (BMSC) are considered the gold standard in tissue engineering and regenerative medicine; however, the adipose-derived stem cells (ASC) have very similar properties and some advantages to be considered a good alternative to BMSC. The molecular mechanisms driving adipogene...