نتایج جستجو برای: osteogenesis

تعداد نتایج: 16229  

2013
Adrienne Moul Amanda Alladin Cristina Navarrete George Abdenour Maria M. Rodriguez

Osteogenesis imperfecta is a rare connective tissue disorder characterized by bone fragility and low bone density. Most cases are caused by an autosomal dominant mutation in either COL1A1 or COL1A2 gene encoding type I collagen. However, autosomal recessive forms have been identified. We present a patient with severe respiratory distress due to osteogenesis imperfecta simulating type II, born t...

Journal: :FEBS Letters 2021

AlkB homolog 5 (ALKBH5) has been reported as a key m6A demethylase that is involved in development and diseases; however, the function of ALKBH5 osteogenesis remains unknown. In this study, we report mRNA protein expression were upregulated during osteoblast differentiation knockdown suppressed differentiation, mineralization, osteogenic biomarkers. Conversely, overexpression promoted osteogene...

Journal: :Tissue engineering. Part A 2010
Karin A Payne Laura B Meszaros Julie A Phillippi Johnny Huard

Skeletal muscle-derived stem cells (MDSCs) can undergo osteogenesis when treated with bone morphogenetic proteins (BMPs), making them a potential cell source for bone tissue engineering. The signaling pathways that regulate BMP4-induced osteogenesis in MDSCs are not well understood, although they may provide a means to better regulate differentiation during bone regeneration. The objective of t...

2017
Chao Liu Jian Yong Dong Lin Lin Yue Shao Hua Liu Yi Wan Hong Liu Wan Ye Tan Qian Qian Guo Dong Zhang

Endosseous titanium (Ti) implant failure due to poor biocompatibility of implant surface remains a major problem for osseointegration. Improving the topography of Ti surface may enhance osseointegration, however, the mechanism remains unknown. To investigate the effect of modified Ti surface on osteogenesis, we loaded rapamycin (RA) onto nano-hydroxyapatite (HAp) coated Ti surface which was aci...

2016
Agnieszka A. Janeczek Rahul S. Tare Edoardo Scarpa Ines Moreno‐Jimenez Caroline A. Rowland Dominic Jenner Tracey A. Newman Richard O. C. Oreffo Nicholas D. Evans

Activation of the canonical Wnt signaling pathway is an attractive anabolic therapeutic strategy for bone. Emerging data suggest that activation of the Wnt signaling pathway promotes bone mineral accrual in osteoporotic patients. The effect of Wnt stimulation in fracture healing is less clear as Wnt signaling has both stimulatory and inhibitory effects on osteogenesis. Here, we tested the hypot...

2017
June Seok Heo Seung Gwan Lee Hyun Ok Kim

Mesenchymal stem cells (MSCs) differentiate into multiple lineages and are a promising source of cells for clinical use. Previously, we found that the gene distal‑less homeobox 5 (DLX5) is specifically expressed in MSCs with osteogenic potential. Understanding the mechanism of osteogenesis is necessary for successful bone regeneration using MSCs. The aim of this study was to examine the functio...

Journal: :journal of research in medical sciences 0
mahmoud omranifard associate professor, department of plastic surgery, school of medicine, isfahan university of medical sciences, isfahan, iran hossein abdali associate professor, department of plastic surgery, school of medicine, isfahan university of medical sciences, isfahan, iran yousef shafaiee resident, department of plastic surgery, school of medicine and student research committee, isfahan university of medical sciences, isfahan, iran payam kabiri department of biostatics and epidemiology, school of public health, tehran university of medical sciences, tehran, iran farzaneh aminpour medical education research center, isfahan university of medical sciences, isfahan, iran and department of health information management, school of health management and information sciences, tehran university of medical sciences, tehran, iran amir mehdi ansari isfahan university of medical sciences, isfahan, iran

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background : distraction osteogenesis is an established option for reconstruction of amputated fingers. in contrast to the primary method of distraction osteogenesis, using kirschner wire (k-wire) as an internal fixator is not common today. this study was conducted to evaluate distraction osteogenesis with and without k-wi...

Journal: :Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002
Louis C Gerstenfeld Johanna Cruceta Colleen M Shea Kuber Sampath George L Barnes Thomas A Einhorn

During endochondral bone development cartilage formation always precedes that of bone, leading to the hypothesis that chondrocytes provide inductive signals for osteogenesis. To test this hypothesis, C3H10T1/2 mesenchymal stem cells were cocultured in membrane separated trans-well culture chambers with nonhypertrophic chondrocytes, hypertrophic chondrocytes, calvaria osteoblasts, or tendon fibr...

Journal: :Pediatrics 2007
Francis H Glorieux

Until recently, medical management of osteogenesis imperfecta, a genetic disorder of reduced bone mass and frequent fractures, was elusive, and treatment was focused on maximizing mobility and function. The introduction of bisphosphonates for the treatment of osteogenesis imperfecta 14 years ago changed this paradigm. Cyclic intravenous pamidronate therapy leads to an increase in bone density a...

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