Pregnant rats were ovariectomized on day 14 of pregnancy (sperm = day 1) and daily injected with 4 mg progesterone. The intrauterine pressure and volume of the conceptus with placenta of these rats and intact normal pregnant rats were measured every morning between day 14 and 20 of pregnancy. The average volume of the conceptus in both groups increased at an almost constant rate until day 18 of...

INTRODUCTION The role of ovarian hormones and nitric oxide in learning and memory has been widely investigated. OBJECTIVE The present study was carried out to evaluate the effect of the nitric oxide synthase (NOS) inhibitor, N (G)-nitro-L-arginine methyl ester (L-NAME), on the ability of estradiol to improve learning in OVX rats using the Morris water maze. METHODS Forty rats were divided i...

BACKGROUND Ghrelin is a hormone which has effects on the secretion of growth hormone, the gastrointestinal system, the cardiovascular system, cell proliferation and the reproductive system. OBJECTIVES The aim of this study is to investigate structural changes in the uterine tissue and to assess ghrelin immunoreactivity in the endometrium as a result of bilateral ovariectomization of rats. M...

The effect of amylose content on digestibility of starch in the small intestine and on the concentration of plasma lipid were studied in ileorectostomized rats and in ovariectomized rats, respectively. Seven kinds of starch with different amylose content (0, 27, 54, 62, 76, 79, 86 %) were used as test starch, which contained 0.4, 5.6, 37.1, 40.2, 45.6, 36.9 and 36.1 % resistant starch (RS), res...

The effect of 17beta-estradiol on venous function was investigated in ovariectomized rats with heart failure. Rats (50-60 days old) were ovariectomized and implanted with 60-day-release pellets that contain 17beta-estradiol (1.5 mg) or vehicle. The left coronary artery was ligated 7 days later. Another group of ovariectomized rats was given vehicle pellets and then a sham operation was performe...

INTRODUCTION Osteoporotic fractures are common during osteoporotic states. Piper sarmentosum extract is known to possess antioxidant and anti-inflammatory properties. OBJECTIVES To observe the radiological changes in fracture calluses following administration of a Piper sarmentosum extract during an estrogen-deficient state. METHODS A total of 24 female Sprague-Dawley rats (200-250 g) were ...

This study investigates the proliferative and osteogenic role of marrow stromal/osteoprogenitor cells in the development of the cortical bone deficit in ovariectomized (OVX) female rats. In vitro, clonal growth of marrow stromal cells from OVX rats was significantly impaired (vs. sham-operated controls). Yet in vivo, cells from sham-operated and OVX rats had equal osteogenic potential in severa...

objective(s): menopause and diabetes obviously increase the risk of cardiovascular disease in women. the aims of the present study were to evaluate the effects of ovariectomy in type 2 diabetes on the histology and expression of mirna-29, mirna-133, igf-1 and bcl-2 genes and bcl-2 protein and caspase 3 activity in the hearts of female rats. materials and methods: forty female wistar rats were d...

To explore sex differences in cardiovascular function under stress, we analyzed plasma levels of glucose, C-reactive protein (CRP), uric acid and cholesterol in male, female and ovariectomized rats under acute and chronic stress. Glucose tolerance test (GTT) was performed in all rats before any stress was performed, as well as later in the chronic stress experiment. GTT in control animals showe...

from the right side of the rat were used to determine the radioactivity contained within the mammary teat, fat pad, and vascular areas, while those from the left side were separated into parenchymal cell and fat cell fractions. The intracellular lipid of the parenchymal cells was extracted and quantitated. Although the pattern of carcinogen uptake and clearance by the parenchymal cell intracell...