The purpose of this study was to verify the effect of cordycepin on ovariectomized osteopenic rats. Fifty Wistar female rats used were divided into 5 groups: (1) sham-operation rats (control), (2) ovariectomized (OVX) rats with osteopenia, and (3) OVX'd rats with osteopenia treated with cordycepin (5 mg, 10 mg, and 20 mg) for 8 weeks. After the rats were treated orally with cordycepin, serum al...

We investigated the regulatory roles of miR-141 and RICTOR genes in osteoporosis (OP) explored potential therapeutic value OP by targeting gene. The role as regulators ovariectomized (OVX) rats was determined using RT-qPCR assays models OVX rats. their expression levels related clinical features were further analyzed. functional miR-141/RICTOR pathway plasmids. lowly expressed rats, while gene ...

Abstract The effectiveness of calcium depends on its source, i.e., salt it is supplied with. This study aimed to determine the effects lactate in diet inflammation and oxidative stress markers ovariectomized rats. A total 40 female Wistar rats were included this study, which divided into four groups. control group was fed a standard diet, whereas remaining three groups provided containing carbo...

We report on the modulatory effects of chronic subcutaneous or oral estrogen and LY117018, a selective estrogen receptor modulator, on the release of nitric oxide in rings of rat aorta studied under isometric conditions. Dilator responses to acetylcholine (ACh; 10[8] to 10[-5] M) were obtained in phenylephrine (PE; 2 microM)-contracted aorta, and constrictor dose-response curves to PE (10[-8] t...

Objectives The role of isoflavones in pulmonary structure and function during menopause is not well studied. Moreover, the important role of estrogen in the physiological function of respiratory system has been revealed. Genistein, as an isoflavone, mimics estrogenic in diabetic and ovariectomized rats. Here, we hypothesized that genistein would reverse changes in the protein expression levels ...

This paper reports the successful pregnancy in rats with only 10-20% of ovarian tissue. Sprague-Dawley female rats of breeding age were divided into five groups: group 1 (completely ovariectomized), the ovaries from both the sides of the rats were removed completely; group 2 (partially ovariectomized, 80-90% of the ovary of each side was removed leaving the remaining tissue in place; group 3 (o...

BACKGROUND Heart failure in women increases around the time of menopause when high-fat diets may result in obesity. The heart produces brain natriuretic peptide (BNP), also known as B-type natriuretic peptide. This aims of this study were to assess cardiac hypertrophy and BNP levels in ovariectomized rats fed a high-fat diet. MATERIAL AND METHODS Forty-eight female Wistar rats were divided into...

The present study was designed to develop an animal model of hypertension and cardiac hypertrophy associated with obesity in female rats. Furthermore, we studied the involvement of the natriuretic peptide system in the mechanisms of these conditions. Obesity was induced in Wistar rats by a high fat diet and ovariectomy. The rats were divided into four groups: ovariectomized or sham-operated wit...

The brain protein synthesis and the plasma concentration of growth hormone (GH) is sensitive to the dietary γ-aminobutyric acid (GABA) in ovariectomized female rats; however, the role of dietary GABA on biomarkers including nerve growth factor (NGF) and choline acetyltransferase for the function of cholinergic neurons remains unknown in ovariectomized female rats. The purpose of this study was ...

OBJECTIVES Previous studies have reported that osteoporosis due to estrogen deficiency influences fracture healing. Transforming growth factor (TGF-b) has been found to be involved in fracture healing via the regulation of the differentiation and activation of osteoblasts and osteoclasts. The current study aimed to determine the effects of estrogen on the expression of TGF-β1 during fracture he...