background: the early stage of copper poisoning is difficult to be clinically diagnosed in sheep and has not been documented clearly yet. objectives: to assess biomarkers in predicting early copper poisoning in sheep, blood samples were collected from several groups of animals from a naturally copper poisoning occurrence in an industrial region. methods: animals were divided into four experimen...

anaplasma ovis infections can cause severe anemia in the acute phase of the disease. in order to investigate the alterations of erythrocyte protective antioxidant mechanisms associated with anemia in sheep experimentally infected with a. ovis, 100 ml heparinized blood was collected from splenectomised sheep that showed 6% a. ovis parasitemia. inoculums of 20 ml blood were administered intraveno...

in order to investigate the effects of peppermint (mentha piperita l.) alcoholic extract on liver injury caused by the oxidant carbon tetrachloride (ccl4), an experiment was performed as a completely randomized design in a factorial arrangement (2 × 2) with 4 replications of 10 broilers each. factors included two levels of peppermint leaf alcoholic extract (0 and 2 ml/kg body weight) and ccl4 (...

conclusions the present study indicated a hepatoprotective effect of loe in diabetic rats. background plants have been the basis for medical treatments throughout much of human history. although the active compounds of many herbal drugs are unknown, they have been widely prescribed by traditional medicine practitioners due to their beneficial effects and low cost. although the primary feature o...

oxidative stress (os), which has been implicated in pathogenesis of many acute and chronic diseases, plays an important role in diverse neurological disorders including depression and anxiety. os is caused by a large amount of reactive oxygen species or impaired enzymatic or non-enzymatic defense against it. os has been suggested to contribute to etiology of mentioned disorders. this review int...

background: the aim of this study was to examine the renoprotective effect of hydro alcoholic sage (salvia officinalis: so) leaves extract against gentamicin-induced nephrotoxicity in rats. methods: in this experimental study forty male sprague dawley rats weighing 200-300 g were randomly divided into 5 groups; (1) the rats without treatment (control), (2) intraperitoneally injected with normal...

introduction: cypermethrin causes its neurotoxic effect through voltage-dependent sodium channels and integral protein atpases in the neuronal membrane. brain and nerve damage are often associated with low residual level of pesticides. in vitro and in vivo studies have also shown that pesticides cause free radical-mediated tissue damage in brain. propolis has antioxidant properties. the main ch...

background: excess reactive oxygen species (ros) in the semen is believed to affect fertility in men. morphologically abnormal sperms and their relation to seminal oxidative stress in infertile and subfertile men are not clear. objective: to correlate various sperm morphological defects with seminal oxidative stress in infertile and subfertile men. materials and methods: the study included 25 p...

Free radicals are normally produced by living organism, at controlled production rate they perform physiological functions as signal transduction molecules. However, situations leading to an overproduction that surpasses antioxidant capacity creates oxidative stress. Consequently, damage to the cell membrane, protein, DNA and cell death are observed. Dairy cattle are susceptible to oxidative st...

Background: Recently, it has been revealed that tyrosine kinase inhibitors (TKIs) act through inducing both oxidative and endoplasmic reticulum (ER) stress in chronic myeloid leukemia cells. However, ER stress signaling triggers both apoptotic and survival processes within cells. Nevertheless, mechanisms by which TKIs avoid the pro-survival effects are not clear. The aim of this study was to ev...