Abstract Over 60% of glioblastomas retain wild-type p53, resulting in potential susceptibility to MDM2 inhibitors. These molecules disrupt the interaction between p53 and its negative regulator MDM2, allowing downstream pathway signaling cell fate decisions including growth inhibition death from cellular stress. We have analyzed clinical samples 10 patients newly diagnosed with glioblastoma mul...

the most frequently mutated tumor suppressor gene found in human cancer is p53. in a normal situation, p53 is activated upon the induction of dna damage to either arrest the cell cycle or else induce apoptosis. however, when mutated, p53 is no longer able to properly accomplish these functions. our aim was to investigate p53 protein alteration in cases of basal cell carcinoma (bcc) and compare ...

background there is a potential risk for malignancy in patients with diabetes mellitus. theoretically, a noninvasive method for detection of precancerous changes can be conducted on oral exfoliated cell smears. objectives in this study, the immunocytochemistry of p53 in exfoliated oral mucosal cells in patients with type 2 diabetes was investigated. patients and methods oral mucosal smears were...

Background: The survival of patients with triple-negative breast cancer subtype undergoing chemotherapy along weight management, physical activity, and diet was examined. In addition, the relationship between Overall Survival (OS) expression P53 Ki 67 investigated. Methods: study conducted on 110 admitted to oncology clinics October 2009 July 2018. underwent five cycles, including Docetaxel, Ep...

Objective Mustard gas (MG) is a poisoning chemical, mutagenic and carcinogenic alkylating agent. It is used during World War I and also Iran-Iraq conflict. The p53 tumor suppressor gene is involved in the pathogenesis of malignant disease. The aim of this study is to determine possible mutation in p53 gene of lung sample from mustard gas exposed patients. Material and Methods Twelve lung bio...

background and objectives: rcc is one of the most common genitourinary cancers. accurate prediction of prognosis would be valuable for adjuvant trial design, counseling and effectively scheduling follow up visits. p53 is a tumor suppressor gene that expresses a protein that involved in both cell-cycle arrests after dna damage and apoptosis. presence of mutated p53 protein in tumors has been rel...