نتایج جستجو برای: pVITRO2

تعداد نتایج: 8  

2013
Yani Zhang Dezhi Fu Hao Chen Zhentao Zhang Qingqing Shi Ahmed Kamel Elsayed Bichun Li

As an attempt to increase the resistance to Newcastle Disease Virus (NDV) and so further reduction of its risk on the poultry industry. This work aimed to build the eukaryotic gene co-expression plasmid of neuraminidase (NA) gene and myxo-virus resistance (Mx) and detect the gene expression in transfected mouse fibroblasts (NIH-3T3) cells, it is most important to investigate the influence of th...

ژورنال: Vaccine Research 2017
Abdoli , A, Aghasadeghi, MR, Amiran, MR, Khateri , M, Motevalli, F, Naziri , H, Tahmtan , A, Yavarian , J,

Introduction: Autophagy is a complicated process which is involved in many biological events such as antigen presentation by immune cells.  Beclin1, as a key component of autophagic machinery, plays the main role in the induction and initiation of this process. In the present study, we hypothesized that overexpression of Beclin1 could be useful in autophagy induction as an immunostimulatory str...

Amiri Yekta A Bahraminejad E Fatemi N, Gourabi H Hadi F, Khoshbakht M Sanati MH

Background: Human luteinizing hormone (hLH) stimulates steroid biosynthesis of the ovary, triggers ovulation and prepares androgen production of testicular Leydig cells. LH belongs to the family of glycoprotein hormones that are heterodimers consisting of a common α-subunit and specific β-subunit. hLH is necessary for clinical and infertility treatment. Recombinant DNA technology provides a use...

A Amiri-Yekta A Zomorodipour H Gourabi M Shahriari khalaj MH Sanati N Fatemi S Abolghasemi S Bahrami

a:4:{s:10:"Background";s:897:"Human luteinizing hormone (hLH) belongs to glycoprotein hormones which is composed of two non-covalently linked subunit, α and β. The α-subunit is similar in all glycoprotein hormones, whereas the β-subunit is conferring the hormonal specificity. This hormone has important roles in the growth and maturity of sexual organs and secondary sexual characteristics and st...

A Amiri-Yekta A Zomorodi Pour H Gourabi M Mahdavi Nosrati, MH Sanati N Fatemi

Background Luteinizing hormone (LH) is a heterodimeric glycoprotein composed of alpha and beta subunits.This hormone is secreted from the pituitary gland. LH, in women triggers Menstrual cycle and ovulation. In men, LH stimulates production of testosterone, which plays a specialized role in sperm production. Up to day, LH hormone have produced in different ways such as codon optimization and al...

A Amiri Yekta H Gourabi M Shahmohammadi, MH Sanati N Fatemi

Background Follicle stimulating hormone (FSH)- a hetrodimeric glycoprotein- is secreted by pituitary gland. This hormone stimulates growth and maturation of the follicles in females and sperms in male. Up to now, glycoprotein hormones such as FSH have produced in different cell lines. Among of the mammalian expression systems, the Chinese hamster ovary cells (CHO) have taken into consideration ...

ژورنال: دانشور پزشکی 2019
تیموریان, شهرام, رسولی, ایرج, رضایی, مریم, شهابی یونسی, امیرحسن, موسیوند, اعظم,

Background and Objective: FSH is a heterodimeric glycoprotein that performs an important role in the regulation of reproductive processes. Over the past decades, injectable gonadotrophins have played a leading role in the treatment of infertility. The production of FSH in the country is one of the main goals around this drug. The aim of this study was to produce a semi- industrial recombinant F...

تیموریان, شهرام, سرابی‌نژاد, زهره, نوری اینانلو, داود,

Background: Infeliximab is a form of chimeric antibody which neutralizes the most important inflammatory cytokine, TNF-a, in inflammatory disorders. The aim of current study was to pilot expression of chimeric infliximab in Chinese Hamster ovary (CHO) cells. Methods: In this research study, pVITRO2-neo-mcs vector that consist of infliximab light chain and heavy chain was used to transform in...

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