Streptococcus mutans is the main microorganism associated to dental caries; it adheres to the dental enamel by interacting with the acquired film's proteins and the cell surface adhesin, called variously antigen PAc. At least two distinct sites in PAc interact with salivary receptors in vitro, these are within residues 816-1213, the most conserved portion of PAc, and within residues 186-469, th...

The prognosis for PaC is extremely poor: it has the lowest five-year survival of all cancers, only 6% [6], and this rate has not changed during the last 40 years [7]. It depends on the late diagnosis of the disease: in the presence of the aspecific symptoms, PaC is often in an advanced stage, which means that the possibility of a curative surgical intervention is low. Screening PaC in an asympt...

The notion of finding a solution that is approximately optimal with high probability was recently introduced to the field of heuristic search, formalized as Probably Approximately Correct Heuristic Search, or PAC search in short. A big challenge when constructing a PAC search algorithm is to identify when a given solution achieves the desired sub-optimality with the required confidence, allowin...

Unsafe abortion is a significant contributor to maternal mortality in Nigeria, and treatment of postabortion complications drains public healthcare resources. Provider estimates of medications, supplies, and staff time spent in 17 public hospitals were used to estimate the per-case and annual costs of postabortion care (PAC) provision in Ogun and Lagos states and the Federal Capital Territory. ...

The chloride penetration resistance of phosphoaluminate cement (PAC) concrete was investigated in this study. The effects of mixture proportioning parameters, including cement content, water–cement ratio (w/c), and superplasticizer content on chloride ion penetration resistance of PAC concrete were investigated by the rapid chloride migration test (RCM). The result shows that the increase of ce...

BACKGROUND AND PURPOSE Paclitaxel (PAC) is associated with chemotherapy-induced neuropathic pain (CIPN) that can lead to the cessation of treatment in cancer patients even in the absence of alternate therapies. We previously reported that chronic administration of the non-psychoactive cannabinoid cannabidiol (CBD) prevents PAC-induced mechanical and thermal sensitivity in mice. Hence, we sought...

The phosphorus activation coefficient (PAC, the ratio of available P to total P) is an important indicator of soil P availability and the transformation of P fractions. Understanding the details of the PAC is useful to estimate soil available P status and to provide P management guidance. In this research, soils from five long-term (23 years) fertilization treatments in three croplands were sel...

BACKGROUND Despite the recently reported drop in the overall death rate from cancer, the estimated survival rate and number of deaths from oral cancer remain virtually unchanged. Early detection efforts, in combination with strategies for prevention and risk-reduction, have the potential to dramatically improve clinical outcomes. The identification of non-toxic, effective treatments, including ...

BACKGROUND The pulmonary artery catheter (PAC) continues to be used for monitoring of hemodynamics in patients undergoing coronary artery bypass graft (CABG) surgery despite concerns raised in other settings regarding both effectiveness and safety. Given the relative paucity of data regarding its use in CABG patients, and given entrenched practice patterns, we assessed the impact of PAC use on ...

CONTEXT Randomized clinical trials (RCTs) evaluating the pulmonary artery catheter (PAC) have been limited by small sample size. Some nonrandomized studies suggest that PAC use is associated with increased morbidity and mortality. OBJECTIVE To estimate the impact of the PAC device in critically ill patients. DATA SOURCES MEDLINE (1985-2005), the Cochrane Controlled Trials Registry (1988-200...