Pantoprazole(®) is one of the leading proton pump inhibitors (PPIs) used in the treatment of a variety of diseases related to the upper gastrointestinal tract. However, studies have shown an increased risk of developing gastric cancer, intestinal metaplasia and hyperplasia of endocrine cells with prolonged use. In the present study, the somatic mutation and recombination test (SMART) was employ...

DESCRIPTION The active ingredient in PROTONIX (pantoprazole sodium) Delayed-Release Tablets and PROTONIX (pantoprazole sodium) For Delayed-Release Oral Suspension is a substituted benzimidazole, sodium 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl] sulfinyl]1H-benzimidazole sesquihydrate, a compound that inhibits gastric acid secretion. Its empirical formula is C16H14F2N3NaO4S x 1.5...

Objective: Famotidine is an H2 receptor antagonist (H2RA) and has been shown to have antiviral properties in in-vitro studies. Pantoprazole one of the proton pump inhibitors (PPI). In this study, it was aimed compare efficacy with treatment COVID-19.
 Material-method: Patients who were hospitalized given famotidine pantoprazole for at least 48 hours included study. Demographic, clinical la...

Although proton pump inhibitors are widely used, allergic reactions to this group of drugs are rarely reported. In this paper we present the case of a patient who developed a delayed reaction to pantoprazole. A 35-year-old female patient complained of generalised erythema with intense itching and desquamation for three weeks before consulting (Fig. 1). The rash was first noticed five days after...

background the prevalence of peptic ulcer disease in hemodialysis patients is more than the general population. they are also more prone to complications including upper gastrointestinal bleeding. the aim of this study was to compare the efficacy of 14 days hybrid regimen with 14 days triple therapy for helicobacter pylori ( h . pylori ) eradication in hemodialysis patients. methods forty hemod...

Although rare, anaphylactic reactions induced by proton pump inhibitors have been reported. The presence of cross-reactivity between different members of the group is not clear. We studied 9 patients with adverse reactions to omeprazole. Clinical symptoms appeared immediately in 8 patients and after 4 hours in 1. Symptoms ranged from urticaria/angioedema in 7 cases to anaphylaxis in 2 cases. Sk...

S Benzimidazoles act as good ligand to transition metal ions and they exhibit several coordination modes. The synthesis of hetero-chelates of the type ML2.2H2O has been reported here.The metal complex of Co(II) and Ni(II) Complexes have been synthesized with 6-(difluoromethoxy)-2-[(3,4dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzo[d]imidazole (Pantoprazole). Pantoprazole is a proton pump inhibi...

Methods Ten patients were evaluated (6 M:4 F; age 41.7 ± 4.3 y; admission APACHE II score 19.4 ± 1.9; pantoprazole n = 4, and placebo n = 6) from a larger prospective study, in which 209 mechanically ventilated patients were randomised to receive IV pantoprazole (40 mg) or placebo in a double-blind fashion. Patients who received ≥ 5 doses of pantoprazole/placebo (80 patients in total) were elig...

A simple, sensitive and precise high performance liquid chromatographic method for the analysis of Pantoprazole sodium and lansoprazole has been developed, validated and used for the determination of compounds in commercial pharmaceutical products. The compounds were well separated an isocratically on a C18 column [Use Inertsil C18, 5μ , 150 mm x 4.6 mm] utilizing a mobile phase consisting of a...