Aims: To evaluate the hepatoprotective activity of Vitex negundo Linn. and Moringa oleifera Lam. In paracetamol induced hepatotoxicity in rats. Materials and Methods: Liver damage was induced in 42 albino rats by paracetamol (1 g/kg P.O.) once daily for a period of 7 days. Silymarin was taken as the standard drug in a dose of 25 mg/kg P.O. Albino Wistar rats (150-200 g) were divided into groups...

This study was carried out to investigate the hepatoprotective effect of the aqueous extract of Kohautia grandiflora on paracetamol induced hepatotoxicity in rats. A total of 20 albino rats of the Wister strain weighing 120-180 g were used for the study. The animals were divided into 4 groups of 5-rats each [I-IV]. Groups I, II and III served as the normal, paracetamol and plant extract control...

Liver being vulnerable to exogenous substances makes disease associated with it a matter of worldwide concern. Several research thus focus on hepatoprotection .Preventive and therapeutic activity plants as hepatoprotective agent is topic interest for researchers. Hepatotoxic agents like carbon tetrachloride, paracetamol, isoniazide etc. increase the serum biomarkers liver where ALT more specifi...

Drug toxicity is a long-standing concern of modern medicine. A typical anti-pain/fever drug paracetamol often causes hepatotoxicity due to peroxynitrite ONOO- . Conventional blood tests fail to offer real-time unambiguous visualization of such hepatotoxicity in vivo. Here we report a luminescent approach to evaluate acute hepatotoxicity in vivo by chromophore-conjugated upconversion nanoparticl...

A new isoflavonoid, 5,6-dimethoxy-2',3'-methylenedioxy-7-C-β-d-gluco-pyranosyl isoflavone was isolated from the seeds of Lepidium sativum L. along with two known isoflavonoids, 7-hydroxy-4',5,6-trimethoxyisoflavone and 7-hydroxy-5,6-dimethoxy-2',3'-methylenedioxyisoflavone. The structures of all compounds were elucidated with NMR spectrometry. Compounds 1, 2 and the new isoflavonoid 3 were eval...

Copyright  2014 irjpbs The aim of this work is to study the hepatoprotective effect of polyherbal formulations contains some Indian medicinal plant. The three different herbal formulations obtained from different medicinal plant extracts were evaluated for hepatoprotective in rats by induced liver damage by paracetamol. Paracetamol (3g/kg, p.o) was administered a single dose to induce hepatoto...

Role of Liv.52, a polyherbal formulation, in regulating the sodium pump in hepatic injury induced by paracetamol was investigated. Alterations in sodium pump were induced by chronic administration of paracetamol at the dose of 500 and 1000 mg/kg b. wt. for 28 days. Serum alanine aminotransferase (ALT), Na-K-ATPase activity estimation and histology of liver were studied. Chronic administration o...

Abstract Background Drug metabolism is crucial to attaining the therapeutic index of any drug. The and elimination drugs are governed mainly by P-glycoprotein (P-gp) Cytochrome P450 (CYP). Paracetamol mostly used as analgesic antipyretic agent. paracetamol primarily via Glucuronidation sulphation at doses. About 5–10% metabolized CYP mediated pathway. 2E1 (CYP2E1) responsible for forming a toxi...

In the present study, we have chosen a plant named Allium cepa Linn (Liliaceae) to evaluate its hepatoprotective activity in experimental animals. Different pharmacological activities are reported with different parts of this plant. Some of its medicinal properties reported are as stimulant, diuretic, anti-tubercular, anthelmintic, and used for various diseases like diabetes, skin diseases, rhe...