Objectives-The present study was designed 1. To achieved maximum yield of bioactive extract from the plant through extraction process. 2. investigated phytochemicals constituents. 3. determined pharmacological screening quercetin against hepatotoxicity. Methods- Crude extracts Moringa oleifera leaves were prepared using various solvents petroleum ether, chloroform, ethanol, methanol in successi...

The poor predictability of human liver toxicity is still causing high attrition rates drug candidates in the pharmaceutical industry at non-clinical, clinical, and post-marketing authorization stages. This part caused by animal models that fail to predict various adverse reactions (ADRs), resulting undetected hepatotoxicity non-clinical phase development. In an effort increase prediction hepato...

Background/Aim: Drug-induced liver injury is one of the major causes acute failure. Under current circumstances pandemic COVID-19, use paracetamol which has a proven hepatotoxic effect increased. This prompts search for novel agents with hepatoprotective properties. The purpose this article was to evaluate activity cryoextract placenta (CEP) on model paracetamol-induced hepatitis. Methods: stud...