LINKED ARTICLE This article is commented on by Bateman DN and Dear JW. Should we treat very large paracetamol overdose differently? Br J Clin Pharmacol 2017; 83: 1163-5. https://doi.org/10.1111/bcp.13279 AIMS: Treatment of paracetamol (acetaminophen) overdose with acetylcysteine is standardized, with dose determined only by patient weight. The validity of this approach for massive overdoses has...

Abstract Background Drug-induced hepatotoxicity is one of the most important causes liver dysfunction. Acetaminophen (paracetamol) an analgesic-antipyretic drug generally considered safe but its overdose may cause toxicity. Marine macro-algae (seaweeds) especially brown seaweeds possess unique biological activities including hepatoprotective potential. The current study focused on effect differ...

Introduction: Liver, main organ for biotransformation of drugs, during which most the drugs are lipophilic in nature made hydrophilic by biochemical processes liver cells resulting into water-soluble products get excreted urine or bile. Adverse drug reactions (ADRs) pertaining to liver, can be mainly two types, predictable dose dependent and idiosyncratic. To counter oxidative stress cellular d...