Paracetamol, one of the most widely used pain-relieving drugs, is deacetylated to 4-aminophenol (4-AP) that undergoes fatty acid amide hydrolase (FAAH)-dependent biotransformation into N-arachidonoylphenolamine (AM404), which mediates TRPV1-dependent antinociception in brain rodents. However, paracetamol also converted liver-toxic metabolite N-acetyl-p-benzoquinone imine already at therapeutic ...

OBJECTIVES Paracetamol overdose belongs to frequent calls to Toxicological Information Centre (TIC) in the Czech Republic and to the National Toxicological Information Centre (NTIC) in Slovakia. The aim of the study was to evaluate outcomes and side effects of paracetamol overdose in both countries. METHODS Data concerning paracetamol poisoning extracted from TIC and NTIC databases 2000-2013 ...

P ublic health interventions are usually implemented without any attempt to prospectively evaluate them with an experimental research design. Thus the only way to evaluate the outcome of the intervention is to describe what happened before and after its implementation. In a new study published in PLoS Medicine, Morgan et al. have examined the change in deaths attributed to paracetamol (acetamin...

the ethanol extract of bacopa monnieri linn. (schrophulariaceae) aerial parts (ebm) was investigated for any in vitro and in vivo antioxidant and hepatoprotective effects. ebm was prepared and estimation of total phenolics was carried out. further, the antioxidant activity of ebm was studied using four in vitro models. the amount of total phenolics was estimated to be 47.7 (g of pyrocatechol eq...