The present study was designed to investigate the synergistic hepatoprotective effect of Silymarin in combination with standardised extracts of Picrorrhiza kurroa, Phyllanthus amarus, Tephrosia purpurea, Asparagus racemosus plants against experimental hepatotoxicity induced by administration of Paracetamol (3g/kg; p.o) and Carbontetrachloride (1ml/kg; s.c) in wistar rats. Paracetamol and CCl4 i...

Iatrogenic Paracetamol toxicity is a potentially life-threatening yet avoidable cause of acute liver failure. Unfortunately, several cases have recently been reported nationally (1,2). The impetus behind our project was a recent case of iatrogenic Paracetamol induced hepatotoxicity within our trust, a London-based District General Hospital. According to the British National Formulary, for adult...

Paracetamol (acetaminophen) poisoning is common throughout the world. The management of nonstaggered (acute) paracetamol overdose is based on the plasma paracetamol concentration plotted on a treatment nomogram. In the UK there are two treatment lines on this nomogram, with the lower treatment line used for individuals felt to be at 'high risk' of paracetamol-related hepatotoxicity either as a ...

OBJECTIVE To evaluate the long term effect of legislation limiting the size of packs of analgesics sold over the counter. DESIGN Before and after study. SETTING Suicides in England and Wales, data from six liver units in England and Scotland and five general hospitals in England, and UK data on sales of analgesics, between September 1993 and September 2002. DATA SOURCES Office for Nationa...

Background & Aim: The human body has the liver as one of its largest organs. It serves as the major site for metabolism and excretion. Injury to the liver or impairment of its functions may complicate one’s health and therefore, constitutes one of the serious public health challenges. The ethanol seed extract of Citrus paradisi Macfad (CPE) was carried out to evaluate ...

AIM: This study was conducted to study the hepatoprotective property of Hemidesmus indicus (L.) R.Br. roots. METHODS: Hepatoprotective properties of the methanol extract of the roots of H. indicus var. pubescens were evaluated on paracetamol induced hepatotoxicity. Hepatotoxicity was induced in albino Wistar rats by the administration of paracetamol (1g/kg), p.o. for 7 days. Methanol extract of...

Hepatoprotective activity of ethanol extract of Haldinia cordifolia against paracetamol induced hepatic damage in albino rats was observed. In the present study the effect of ethanol extract of Haldinia cordifolia on serum markers such as SGPT, SGOT, ALP and Serum total bilirubin, anti oxidant studies such as SOD, CAT and LPO and Histopathological studies have been studied to find out the possi...

Protective action of Livol (a herbal formulation) against paracetamol induced experimental hepatotoxicity was observed in dog. Increased values of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, serum total cholesterol and its fractions, globulin, icterus index, prothrombin time and bromosulphalein retention by paracetamol (250 mg/kg, once orally) were decrease...

Objective: Ethanol extract of Cajanus cajan (L.) Millsp. (Pigeonpea) leaves (ECC) was investigated for its hepatoprotective activity. Methods: Different groups of Wistar albino rats were administered with paracetamol (500 mg/kg, p.o., once daily for 7 days) for induction of hepatotoxicity. ECC (100, 200 and 300 mg/kg/day) and silymarin (25 mg/kg/day) were administered to the paracetamol induced...