The accessibility and simplicity of the zebrafish embryo have allowed researchers to make a detailed characterization of pathfinding by identifiable growth cones. The growth cones follow precise cell-specific pathways to their targets. Analyses of pathfinding in mutant and experimentally manipulated wild type embryos have shown that growth cones accomplish this by interacting with specific cell...

To address how the highly stereotyped retinotectal pathway develops in zebrafish, we used fixed-tissue and time-lapse imaging to analyze morphology and behavior of wild-type and mutant retinal growth cones. Wild-type growth cones increase in complexity and pause at the midline. Intriguingly, they make occasional ipsilateral projections and other pathfinding errors, which are always eventually c...

Cooperative Pathfinding is a multi-agent path planning problem where agents must find non-colliding routes to separate destinations, given full information about the routes of other agents. This paper presents three new algorithms for efficiently solving this problem, suitable for use in Real-Time Strategy games and other real-time environments. The algorithms are decoupled approaches that brea...

Neuronal growth cones navigate over long distances along specific pathways to find their correct targets. The mechanisms and molecules that direct this pathfinding are the topics of this review. Growth cones appear to be guided by at least four different mechanisms: contact attraction, chemoattraction, contact repulsion, and chemorepulsion. Evidence is accumulating that these mechanisms act sim...

Pathfinding problems consist in determining the optimal shortest path, or at least one path, between two points in the space. In this paper, we propose a particular approach, based on methods used in Computational Fluid Dynamics, that intends to solve such problems. In particular, we reformulate pathfinding problems as the motion of a viscous fluid via the use of the laminar Navier-Stokes equat...

The Caenorhabditis elegans genome contains three rac-like genes, ced-10, mig-2, and rac-2. We report that ced-10, mig-2 and rac-2 act redundantly in axon pathfinding: inactivating one gene had little effect, but inactivating two or more genes perturbed both axon outgrowth and guidance. mig-2 and ced-10 also have redundant functions in some cell migrations. By contrast, ced-10 is uniquely requir...