background hepatitis b virus (hbv) infection is a serious global health problem that is associated with huge social and economic costs. early antiviral drugs, such as interferon-α2b, peginterferon-α2a, lamivudine, and adefovir, all have their limitations (such as low responses or safety concerns) in clinical application. telbivudine and entecavir are two of the latest nucleotide drugs and both ...

fresh frozen plasma (ffp) and prothrombin complex concentrate (pcc) reverse oral anticoagulants such as warfarin. we compared the standard dosage ffp and pcc in terms of efficacy and safety for patients with mechanical heart valves undergoing interventional procedures while receiving warfarin. fifty patients were randomized (25 for each group) with mechanical heart valves [international normali...

in daily life, complexity results from countless factors. culture, environment, social and economic status and physical ability all contribute, and all complicate managing ill health. pharmacists bear witness to many of these complexities and increasingly must care for what have come to be known as ‘complex patients’.  the issue of  ‘complex patients’ is one that has been addressed by healthcar...

Objective(s): We performed a phase IIa clinical trial of trans-1-amino-3-18Ffluoro-cyclobutane carboxylic acid (anti-18F-FACBC), a synthetic amino acid analog for PET, in patients with metastatic prostate cancer. Methods: The study subjects consisted of 10 untreated prostate cancer patients having lymph node and/or bone metastasis. Five patients underwent whole-body PET 5 and 30 min after intra...

background and aims: there are different causes for brain death including head trauma, cerebrovascular accidents and intracranial space-occupying lesions. the present study was aimed to determine the causes of brain death in chahar mahal and bakhtiari province due to high turnover of trauma in this area during 2003 to 2013. methods: this study was based on routine data and was conducted on all ...

BACKGROUND Patients have the potential to provide feedback on the safety of their care. Recently, tools have been developed that ask patients to provide feedback on those factors that are known to contribute to safety, therefore providing information that can be used proactively to manage safety in hospitals. The aim of this study was to investigate whether the safety information provided by pa...

The virtual class 15] construct was rst introduced in the language Beta to provide added expressiveness when used with inheritance. Unfortunately, the virtual class construct in Beta is not statically type-safe. In this paper we show how a generalization of the semantics of object-oriented languages with a MyType construct leads to a variant of virtual classes which needs no run-time checks. Th...

The Virginia Internet safety program is the first statewide educational strategy to improve children's Internet safety. It aims to improve children's Internet safety knowledge through a developmentally appropriate and highly interactive online program. To assess the initial effect of this program, 1,379 fourth graders were assessed with a questionnaire covering ten aspects of Internet safety kn...