BACKGROUND The molecular mechanisms of tumor suppressor gene DLEC1 are largely unknown. OBJECTIVES In this study, we established DLEC1 over-expression stable clones to study the cellular function of DLEC1 in the colorectal cancer cell line, HCT116. MATERIALS AND METHODS Stable clones with DLEC1 over-expression were first established by the transfection of DLEC1 expression construct pcDNA31D...

conclusions dlec1 suppresses tumor cell growth the presence of ap-2α2 and stimulates cell proliferation in the down-regulation of ap-2α2 in dlec1 over-expression stable clones of htc116. results the dlec1 over-expression was found to reduce the number of colonies in colony formation and to induce g1 arrest in seven clones, and apoptosis in one clone in the cell cycle analysis. furthermore, rega...