A new class of conformationally rigid phosphino-oxazoline ligands 3 were synthesized via an efficient ortho-substitution of phenyl glycinol as the key step. Divergent synthetic routes for easy ligand modulation, as well as a procedure suitable for scale-up synthesis, were established. The catalytic potential of ligands 3 has been demonstrated in the highly enantioselective Ir-catalyzed hydrogen...

Abstract The isostructural series (Ga,In)Pd 2 and (In,Sn)Pd have been established characterised. Together with the recently discovered (Ga,Sn)Pd , they form a triangle along edges of which electronic, structural combination thereof on chemical physical properties can be explored, e. g. in heterogeneous catalysis. Single‐phase ternary samples Ga 1‐ x In Pd Sn are synthesised =0.1 substitution st...

Three new porphyrin aminoalkyl dibenzylphosphoramidates were synthesized by nucleophilic aromatic substitution of one p-fluorine atom of 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin (TPPF 20 ) by primary aminoalkyl dibenzylphosphoramidates. The nucleophilic aromatic substitution was promoted by microwave irradiation in N-methyl-2-pyrrolidinone. Attempts to remove the benzyl groups of the pho...

Vacuolar protein sorting 35 (VPS35) was recently reported to be a pathogenic gene for late-onset autosomal dominant Parkinson's disease (PD), using exome sequencing. To date, VPS35 mutations have been detected only in whites with PD. The aim of the present study was to determine the incidence and clinical features of Asian PD patients with VPS35 mutations. We screened 7 reported nonsynonymous m...

Evidence of a Wheland intermediate in carboxylate-assisted C−H activation was found using DFT calculations when the Pd(IV) catalyst species postulated as active (ACS). In order to delineate reaction mechanism Pd-catalyzed bisarylation 3-alkylbenzofuran, five hypothetical species, [Pd(OAc)(PMe3)(Ph)] (I), [Pd(OAc)2] (II), [Pd(OAc)2(PMe3)] (III), [Pd(OAc)2(Ph)]+ (IV) and [Pd(OAc)2(PMe3)(Ph)]+ (V)...

the ball and beam system is one of the most popular laboratory setups for control education. in this paper, we design a fuzzy pd cascade controller for a ball and beam system using asexual reproduction optimization (aro) technique. the ball & beam system consists of a servo motor, a grooved beam, and a rolling ball. this system utilizes a servo motor to control ball’s position on the beam. chan...

The mechanism of the formation of coumarins via the Pd-catalyzed intramolecular hydroarylation of the C-C triple bond is elucidated computationally, in corroboration with experimental data. It is shown that the reaction follows the concerted metalation-deprotonation (CMD) mechanism. The typically suspected mechanisms of ambiphilic metal ligand activation (AMLA), electrophilic aromatic substitut...

Therapeutic strategies in Parkinson's disease (PD) provide control of motor (nigral) and nonmotor (extranigral) symptoms. Nigral dopamine-related signs and symptoms are addressed by supplementation or substitution of cerebral dopamine, and extranigral nondopamine-related symptoms are treated by addressing specific autonomic, neuropsychiatric and sleep dysfunctions. However, the ultimate goal in...