An intramolecular enantioselective metal-catalyzed dearomatization reaction is described. This procedure allows the dearomatization of naphthalene derivatives through an electrophilic aromatic substitution-type reaction on a Pd(II) intermediate. The high yields and enantioselectivities achieved make this procedure a valuable method for synthetic chemists.

Conceptually new bifunctional chiral ligands were developed. The axially chiral N,N-bidentate phenanthroline ligand (S)-1 was found to be effective for Pd-catalyzed asymmetric allylic substitution of allyl acetate and dialkyl malonate. The intramolecular Lewis basic group from the hydroxybinaphthyl structure of (S)-1 played a pivotal role in the high reactivity and enantioselectivity.

Here, we have used a simple method for polyol synthesis, analysis, and testing of Au/Cu-doped ZnO Ultraviolet (UV) photodetectors (PD). Our results are reported discussed by X-ray diffraction (XRD) to ensure that the manufactured samples show hexagonal wurtzite structure. Transmission electron microscopy (TEM) confirmed nanoparticle growth in sample on surface, which is key improving light resp...

objectives to explore the effect of a selective 10-week corrective exercise with an emphasis on gait training activities (gta) on the number of falls (nofs), fear of falling, functional balance, timed up and go (tug) test among pd patients. background posture instability and unsteady gait disorders in parkinson’s disease (pd) usually contribute to fall-related fractures. fall-related trauma in ...

Parkinson's disease (PD) is characterized by loss of dopaminergic neurons in substantia nigra pars compacta, α-synuclein (α-syn)-rich intraneuronal inclusions (Lewy bodies), and microglial activation. Emerging evidence suggests that CD4+ T lymphocytes contribute to neuroinflammation in PD. Since the mainstay of PD treatment is dopaminergic substitution therapy and dopamine is an established tra...

OBJECTIVES Considering the hypothesis that the high biliary elimination of ceftriaxone could be responsible for the selection of Enterobacteriaceae harbouring high-level AmpC β-lactamase (HL-CASE), the use of ceftriaxone was discontinued in our hospital in 2006 and replaced with cefotaxime. METHODS Antibiotic consumption, expressed as defined daily dose (DDD)/1000 patient-days (PD), and HL-CA...

Parkinson's disease (PD) and schizophrenia (SCZ) are frequent central nervous disorders that have unclear etiologies but that show similarities in their pathogenesis. Since elevated histamine levels in the brain have been associated with PD and SCZ, we wanted to explore whether the Thr105Ile substitution in the histamine N-methyltransferase gene (HNMT-Thr105Ile), which impairs histamine degrada...

The influence of partial substitution of Mg by Pd on the microstructure, mechanical properties and corrosion behaviour of Mg(72-x)Zn(23)Ca(5)Pd(x) (x=0, 2 and 6 at.%) alloys, synthesized by copper mould casting, is investigated. While the Mg(72)Zn(23)Ca(5) alloy is mainly amorphous, the addition of Pd decreases the glass-forming ability, thus favouring the formation of crystalline phases. From ...

BACKGROUND The G2019S mutation is the most common pathogenic substitution in the leucine-rich repeat kinase 2 (LRRK2) gene, which has recently been identified in familial and sporadic Parkinson disease (PD). OBJECTIVES To report the clinical characteristics of PD patients with homozygous LRRK2 6055G>A (G2019S) mutations and to compare them with previously published descriptions of heterozygou...