OBJECTIVE To contribute to decision analysis by estimating utility, defined as an individual's valuation of specific health states, for different pregnancy contexts. STUDY DESIGN Cross-sectional analysis of data from pregnant women recruited at pregnancy testing clinics during June 2014-June 2015. Utility was measured using the visual analog scale (VAS), PROMIS GSF-derived utility, standard g...

Insulin deficiency drives the progression of both type 1 and type 2 diabetes. Pancreatic β-cell insulin expression and secretion are tightly regulated by nutrients and hormones; however, intracellular signaling proteins that mediate nutrient and hormonal regulation of insulin synthesis and secretion are not fully understood. SH2B1 is an SH2 domain-containing adaptor protein. It enhances the act...

Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal human malignancies, with an overall 5-year survival rate of <5%. Genetic analysis of PDAC patient samples has shown that specific disease-associated mutations are correlated with histologically defined stages of neoplastic progression in the ductal epithelium. Activating mutations in KRAS are almost uniformly present in early-stag...

Background: For years, scientists have been striving to identify compounds improve the characteristics and functions of cells for therapeutic applications. Objectives: This study aimed evaluate effect aqueous decoction internal septum walnut kernel (DISWK) on survival, total antioxidant capacity (TAC), cell cycle rat bone marrow-derived mesenchymal stem (rBM-MSCs). We also evaluated expression ...

The compensatory increase in the mass of b-cells in response to peripheral insulin resistance contributes to the prevention of diabetes. Glucokinase-mediated glucose signaling and insulin receptor substrate (IRS)-2-mediated insulin signaling in the b-cells play crucial roles in the proliferation of the b-cells in this process. When the b-cell mass fails to increase to compensate for the increas...

Examination of human fetal pancreatic endocrine cell development can provide further insight in, defining the developmental patterns of endocrine cells and identifying β-cell progenitors. In this study we performed a comprehensive immunohistochemical analysis of human fetal pancreatic sections aged from 7.7 to 38 weeks post conception (wpc), as well as 10 weeks post natal (wpn), and adult secti...

OBJECTIVE Ketosis-prone diabetes (KPD) is an emerging syndrome that encompasses several distinct phenotypic subgroups that share a predisposition to diabetic ketoacidosis. We investigated whether the A-beta- subgroup of KPD, characterized by complete insulin dependence, absent beta-cell functional reserve, lack of islet cell autoantibodies, and strong family history of type 2 diabetes, represen...

In this work, we examine the transferability of a pairwise potential model (derived for MgSiO3 perovskite) to accurately compute the excess energies of the generalized stacking faults (GSF, also called γ-surfaces) in MgSiO3 post-perovskite. All calculations have been performed at 120 GPa, a pressure relevant to the D″ layer. Taking into account an important aspect of crystal chemistry for compl...