DGCR8/Pasha is an essential cofactor for Drosha, a nuclear RNase III that cleaves the local hairpin structures embedded in long primary microRNA transcripts (pri-miRNAs) in eukaryotes. Although our knowledge of pri-miRNA processing has significantly advanced in recent years, the precise role of DGCR8 in this pathway remains unclear. In our present study, we dissect the domains in DGCR8 that con...

Population collapses result from drastic environmental changes, but the sexes may differ in vulnerability. Collapse of the endangered Hawaii creeper (Oreomystis mana) at Hakalau Forest National Wildlife Refuge resulted from food limitation associated with increased numbers of an introduced bird (Japanese white-eye, Zosterops japonicus), which competes with the creeper for food. Both creeper sex...

There are extensive data indicating that some glacial refuge zones of southern Europe (Franco-Cantabria, Balkans, and Ukraine) were major genetic sources for the human recolonization of the continent at the beginning of the Holocene. Intriguingly, there is no genetic evidence that the refuge area located in the Italian Peninsula contributed to this process. Here we show, through phylogeographic...

Whooping Crane (Grus americana) fecal samples were collected from Matagorda Island National Wildlife Refuge (MINWR) during winter and fall of 1993-94 (Winter-1; n = 59), and Aransas National Wildlife Refuge (ANWR) during winter and fall of 1993-94 (n = 102) and 1994-95 (Winter-2; n = 257) to study crane diets and compare patterns of food use in these areas. Food items varied between areas, acro...

Abstract Being-at-home in a particular, determined, world is dangerous for thinking. For thinking to be thinking/becoming, one should not get too comfortable. arrive back home, the same place begins. But how escape that has created who you are, gave purpose and past? How make sure future repetition of Same? break away from something need? In this article, my aim give more solution fundamental p...

Structurally similar double-point modified analogues of 1,25-dihydroxyvitamin D₂ (1,25D₂) were screened in vitro for their pro-differentiating activity against the promyeloid cell line HL60. Their affinities towards human full length vitamin D receptor (VDR) and metabolic stability against human vitamin D 24-hydroxylase (CYP24A1) were also tested. The analogues (PRI-1730, PRI-1731, PRI-1732, PR...

While acute myocardial infarction (MI) is associated with impaired clopidogrel responsiveness, systematic evaluation is lacking due to the inability of functional aggregation-based assays to analyse clopidogrel responsiveness in the presence of glycoprotein IIb/IIIa inhibitors. Using the P2Y12-specific, non-aggregation-based platelet-reactivity-index (PRI) we assessed clopidogrel responsiveness...

This study aimed to quantify concentrations of fifteen perfluoroalkyl acids (PFAAs) in the plasma of American alligators (Alligator mississippiensis) inhabiting wetlands surrounding the Kennedy Space Center (KSC) in Florida, USA located at Merritt Island National Wildlife Refuge (MINWR). Approximately 10 male and 10 female alligators (ntotal = 229) were sampled each month during 2008 and 2009 t...

Abstract What is the relationship between life and trust? This article traces how trust cultivated at Al Ma'wa, a wild animal sanctuary in northern Jordan, where dozens of animals rescued from regional warzone zoos are rehabilitated. At vital , sense that it inextricably linked to what means for live good, ‘natural’, fully life. Yet this also bound up material conditions animals’ enduring capti...

The location in Cornwall (UK) known as Tintagel Island is, fact, a peninsula of type that has been referred to an ‘almost island’ by virtue having many island-like characteristics. is best ancient heritage site and, the modern era at least, access from adjacent cliff lines difficult, requiring steep descent low, narrow isthmus and ascent other side. In 2015 English Heritage (EH) organisation an...