BACKGROUND/AIMS Scientific interest in pentoxifylline has been reawakened owing to the recognised effects of this drug on immune functions, particularly its influence on cytokine production. In a previous study, the authors demonstrated that spiking of organ culture media with endotoxin elicited a marked enhancement in the release of IL-6 and IL-8 from corneal tissue and that these events coinc...

Introduction: Pharmacological blockage of glial activity has been proved useful for treatment of neuropathic pain by lowering proinflammatory cytokines. The present study is to confirm the effect of post-injury administration of pentoxifylline on chronic constriction injury (CCI)-induced neuropathic pain symptoms_ and improved the efficacy of morphine anti-nociception. Methods: Male Wistar ...

Introduction:Among major trauma patients in the emergency department, leading cause of morbidity and mortality is a hemorrhagic shock. The low oxygen flow with hypovolemia believed to play significant role. Hence, supply essential severe massive hemorrhage. This study aimed investigate effect hypoxic condition variable treatments such as pentoxifylline (PTX), glycerol, hypertonic saline (HTS), ...

OBJECTIVES Pentoxifylline, a methylxanthine derivative with significant hemorheologic properties, is used for claudication in patients with peripheral vascular disease, and experimentally for ischemic injury to organs because of its antioxidant and antiinflammatory effects. We used a rat model of severe small intestinal ischemia and reperfusion to determine the ability of pentoxifylline in impr...

BACKGROUND The combination of high PEEP and low tidal volume (V(T)) decreases some risks of mechanical ventilation, including pulmonary overdistention, damage due to cyclic opening and closing of the alveoli, and inflammatory responses that can lead to multiple-organ dysfunction. We hypothesized that high V(T) and high PEEP induce mesenteric microcirculatory disturbances and that those disturb...

results daily administration of 50 mg/kg ptx (groups 1 and 2) decreased the high stress load in repairing osteotomized femurs when compared with the control group. the highest dose of ptx (200 mg/kg) significantly increased the high stress load when compared with the control group (p = 0.030), group 1 (p = 0.023), group 2 (p = 0.008), and group 3 (p = 0.010), per the lsd findings. materials and...

objective(s) the brief interruption of cerebral blood flow causes permanent brain damage and behavioral dysfunction. the hippocampus is highly vulnerable to ischemic insults, particularly the ca1 pyramidal cell layer. there is no effective pharmacological strategy for improving brain tissue damage induced by cerebral ischemia. previous studies reported that pentoxifylline (ptx) has a neuroprote...