A rapid, optimized, and sensitive reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for determination of pentoxifylline in human plasma. The analyte was extracted from the plasma with dichloromethane after addition of 0.2 mL 1 M NaOH. HPLC separation was performed on a C18 analytical column (250 mm × 4 mm i.d.) with acetonitrile–water, 45:55 (v/v), as mo...

Osteoradionecrosis of jaw is one of the significant complications of radiotherapy in head and neck cancer patients. This article reviews pathophysiology and newer treatment options for osteoradionecrosis. Newer modalities of treatment include combination therapy of pentoxifylline and tocopherol for osteoradionecrosis. In this article basic information about pentoxifylline and tocopherol and rec...

background: inflammation is involved in development, progression, and complications of atherosclerotic disease. clinical studies have indicated that the level of monocyte chemoattractant protein 1 (mcp-1), il-18, and adhesion molecules correlates with the severity of atherosclerosis and can predict future cardiovascular events. experimental studies have shown pentoxifylline (ptx) reduces these ...

To date, there are no effective treatment for placental dysfunction in pregnant women with gestational hypertension. Therefore, the purpose of our study was to investigate clinical efficacy proposed method infusion therapy hypertension, which included a complex drugs: pentoxifylline, arginine hydrochloride levocarnitine and rheosorbilact. We observed 73 single fetation, starting from 28 weeks g...

Background The STOPAH trial was a double-blind, 2x2 factorial, phase III randomised clinical trial assessing the treatment of prednisolone and pentoxifylline in patients with severe alcoholic hepatitis; a study that aimed to evaluate 28-day mortality [1]. At the time of trial development, the benefits/harms of pentoxifylline in this patient population were unknown. Prednisolone had a significan...

introduction: the present study used a histological evaluation method to examine the effects of pentoxifylline (ptx) on healing an experimentally-induced pressure sore in a rat model. materials and methods: there were 36 adult male rats used in this study. under general anesthesia and sterile conditions, we used forceps to create one pressure sore on each rat. a double layer of folded skin from...

Contrast-induced nephropathy (CIN) (known as contrast-induced acute kidney injury) occurs as a result of acute worsening of renal function following a procedure with administration of iodine contrasts agent and remains a substantial concern in clinical practices. The purpose of this study is to investigate the preventive effect of Pentoxifylline supplementation on reduction of CIN occurrence af...