Objective: Antiepileptic drugs (AEDs) that are usually used for treatment of epilepsy have substantial side effects and about 30% of patients continue to have seizures with current AEDs therapy. Some herbs which traditionally used in the management of seizures of many rural areas of the developing countries have shown anticonvulsant activity in modern pharmacological bioassays. The aim of the p...

salvia verticillata is one of the salvia species which possesses remarkable antioxidant activity. in the present study, we investigated the possible effects of hydro-alcoholic extract from salvia verticillata plant (sve) in various models of anxiety, depression and seizure in mice. mice were randomly divided into control (saline), sve-treated and standard treatment groups. the sve-treated group...

Acorus calamus has been used for a long time in traditional medicine as a remedy for pain, convulsion, inflammation, and ulcer. In the present work, the analgesic effects of methanolic extract of Acorus calamus roots (MEAC) have been evaluated using acetic acid induced Writhing response and Rat caudal immersion method. Whereas the anticonvulsant effect were investigated by utilizing pentylenete...

Cefazolin injection (3000 mg/kg, i.v.) in mice showed several behavioral excitations such as wild running, jumping, rolling, and finally undergoing severe convulsions followed by death. It's lower doses (500-2000 mg/kg, i.v.) were unable to produce any convulsions or behavioral excitations in mice. However, cefazolin (500 or 1000 mg/kg, i.v.) when administered before different doses of pentylen...

GABA exhibits depolarizing action in the immature neurons due to high intracellular activity of chloride ions. It is maintained by cation-chloride cotransporter NKCC1 which is present in immature brain. Bumetanide is a specific inhibitor of this cotransporter. We studied possible anticonvulsant activity of bumetanide in pentylenetetrazol-induced seizures in three age groups of rat pups (7, 12, ...