delayed neuronal death after seizure attack may be mediated by the induction of apoptosis-pathway. caspase-3, a mammalian cysteine protease, promotes apoptosis after some neurological disorders. neuron regeneration peptides (nrps) are small synthetic peptides that stimulate neural proliferation, migration, and differentiation with no apparent toxicity and high target specificity in cns. in the ...

the pharmacological interaction between cannabinoidergic system and vanilloid type 1 (trpv1) channels has been investigated in various conditions such as pain and anxiety. in some brain structure including hippocampus, cb1 and trpv1 receptors coexist and their activation produces opposite effect on excitability of neurons. in this study, we tested the hypothesis that trpv1 channel is involved i...

Background: Euphorbia pulcherrima belongs to the family: Euphorbiaceae and Genus: Euphorbia. Many species of Euphorbia have been reported as having beneficial properties like anticonvulsive effect. However, little study has been done and published on Euphorbia pulcherrima (Lalupate). In the present study we evaluated the anticonvulsant properties of Euphorbia pulcherrima by using various convul...

introduction: epilepsy is a common central nervous system (cns) disorder characterized by seizures resulting from episodic neuronal discharges. the incidence of toxicity and refractoriness has compromised the clinical efficacy of the drugs currently used for the treatment of convulsions. thus, there is a need to search for new medicines from plant origin that are readily available and safer for...

Epilepsy refers to a clinical syndrome generated by spontaneous seizures in the central nervous system. Epilepsy triggers a complex pathological process including inflammatory response and aquaporin 4 (AQP4) increase. It has been reported that AQP4 helps to enhance the immunological function of the central nervous system in pathological conditions, but the relationship between AQP4 and inflamma...

Article Type Research Article Authors Roohbakhsh A.* PhD, Esmaeili H.1 BSc, Asami Z.1 BSc, Arab Baniasad F.1 MSc, Shamsizadeh A.1 PhD, Rezvani M. E.2 PhD

The study was designed to investigate the effect of various concentrations of cannabidiol (CBD) in rats with chronic epilepsy. The chronic epilepsy rat model was prepared by intraperitoneally injecting pentylenetetrazole to the rats pre-treated with CBD (10, 20 and 50 mg/kg) for 28 consecutive days. Behavioral measurements of convulsion following pentylenetetrazole treatment and morphological c...