Gap junctions play an important role in the synchronized neuronal discharges. The main reason of the epileptic seizures is disruption of this synchronization. Therefore, the aim of the present study is to explore the combination valproic acid with carbenoxolone in pentylenetetrazole-kindled rats. In the first set of experiments, pentylenetetrazole (35 mg/kg intraperitoneally was administered to...

Seizures induced by an acute pentylenetetrazole (50 mg/kg) injection were accompanied by a long-term (at 1-48 h, but not on day 7) decrease in the density (B(max)) of [3H]-diazepam binding to benzodiazepine receptors in rat cerebellar cortex with no change in affinity (K(d)). Kindling for 24 days by daily administrations of pentylenetetrazole (20 mg/kg) led to the same decrease in benzodiazepin...

PURPOSE Mutations that enhance currents through the Ca(2+)- and voltage-gated K(+) channel BK (Slo, maxiK, KCNMA1) have been associated with seizure disorders in both rodent models and humans. Previously we have found that seizures themselves induce a gain-of-function in BK channels that is associated with elevated excitability in neocortical neurons. In this study, we sought to examine whether...

BACKGROUND ATP sensitive potassium channels are widely distributed in central nervous system (CNS) and these channels could be the target in CNS disorders by their modulators. PURPOSE The present study was designed to investigate the anticonvulsant potential of glibenclamide on MES induced seizure and pentylenetetrazole induced seizure in mice. METHODS Seizures were induced in 7 months albi...

background and objective: copper is one of the main micronutrients of body which plays a key role as a cofactor in the function of metabolic enzymes. previous studies have shown that copper sulfate () inhibits long-term potentiation (ltp) in slices of hippocampal ca1 region. whereas ltp is involved in learning and epilepsy, it seems that copper effects on ltp could be associated with its effect...

objective: at present, there are many antiepileptic drugs with a wide range of side effects on the human body. it was assumed that zataria multiflora boiss (z. multiflora) with sedative, anti-spasmodic and anti-inflammatory activity may be effective in the treatment of epilepsy. the aim of the present study was to elucidate the effect of z. multiflora hydroalcoholic extract and its fraction ext...

ryanodine receptor abnormalities has implicated in the generation and maintenance of seizure. dantrolene, a selective ryanodine receptor antagonist, may be a potential drug for the prevention of seizure. therefore, we aimed to clarify the protective effects of dantrolene against pentylenetetrazole seizure in mice. male albino mice were received an intra-peritoneal injection of pentylenetetrazol...

epilepsy is the most frequnt nearological affiction and afflicts 1% about of the worlds population. currently there is an urgent need for the development of novel anticonvulsants with higher levels of potency and lower levels of toxicity. in this paper, a series of new 6-(substituted-phenyl)thiazolo[3,2-b][1,2,4]triazole derivatives were synthesized and tested for their anticonvulsant activity ...

The aim of the present study was to investigate the mechanism underlying the effects of different doses of agmatine in rats with chronic epilepsy. To generate chronic epilepsy models, rats pretreated with different doses of agmatine (20, 40 and 80 mg/kg) were intraperitoneally injected with pentylenetetrazole (35 mg/kg) for 28 consecutive days. Epileptic behavior was observed using behavioral m...

Argyreia speciosa commonly known as Vridha daraka in Sanskrit is one of the important plants used in indigenous system of medicine. The root is regarded as an alternative tonic and useful in the diseases of nervous system. To confirm the veracity of aforementioned claim, we have evaluated the anticonvulsant effect of the extract. In this investigation, the mice were pretreated with different do...