Epilepsy is a chronic disorder of the brain affecting around 50 million people in the world. Up to 30% of epileptic patients do not respond to available drugs and medical therapies. In this paper, anticonvulsant screening of 10 synthesized new derivatives of 1, 4-dihydropyridine-3, 5-dicarboxamides was performed. Anticonvulsant activity was evaluated by intravenous and intraperitoneal pentylene...

In the present study, Solanum melongena Linn. (Brinjal; Solanaceae), was evaluated for its antiepileptic activity against experimental seizures. The roots ethanolic extract of Solanum melongena protected mice against tonic convulsion induced by maximal electroshock, Pentylenetetrazole and Picrotoxin. It was found that ethanolic extract up to a dose of 300 mg/kg p.o. decreased the duration of to...

background: cicer arietinum (chickpea) is one of the most important harvests in the world with high nutritional value. lack of essential oils in the seeds of chickpea is an advantage in search for drug-like molecules with less toxicity. we evaluated anticonvulsant effect of c. arietinum in common animal models of epilepsy. methods: dichloromethane extract was obtained from c. arietinum seeds by...

creatine exerts beneficial effects on a variety of pathologies in which energy metabolism and oxidative stress play an etiological role. creatine supplements have shown beneficial effects on neurological disorders including parkinson's disease, huntington's disease, amyotrophic lateral sclerosis, alzheimer's disease and stroke. however, the potential benefits of creatine for pati...

background and objectives: most antiepileptic drugs that are commonly being used in the clinic have a wide range of unwanted side effects; while some species of pistachioshave been used in the traditional medicine to treat epilepsy. the aim of the present study was to investigate the anticonvulsant effects of the hydroalcoholic extract of pistacia vera l. in pentylenetetrazole (ptz)-induced che...

Our working hypothesis is that constant interpulse interval (IPI) electrical stimulation would resonate with endogenous epileptogenic reverberating circuits, inducing seizures, whereas a random interinterval electrical stimulation protocol would promote desynchronization of such neural networks, producing an anticonvulsant effect. Male Wistar rats were stereotaxically implanted with a bipolar e...

OBJECTIVE The present study was designed to investigate the anticonvulsant potential of nickel which is shown to selectively block t-type calcium channels by using nickel choride on pentylenetetrazole (80 mg/kg) induced seizure activity model in mice. MATERIALS AND METHODS Seizures were assessed in terms of onset of Straub's tail phenomenon and onset of jerky movements of the whole body, conv...

Erythrophleum ivorense is used traditionally for many ailments such as convulsion, swellings, pain and emesis. Therefore, this study aimed to investigate the anticonvulsant and sedative activities of extracts of Erythrophleum ivorense stem bark in mice. Anticonvulsant effect of the extracts was assessed using picrotoxin, pentylenetetrazole and strychnine-induced convulsion and sedative effect w...

The neurobiological activity of Parawixin 10, isolated from Parawixia bistriata spider venom, was investigated. Cannulas were implanted in the lateral ventricles of Wistar rats (200-250 g, n=6-8 per group) to perform anticonvulsant and behavioral assays, and synaptosomes from cerebral cortices of male Wistar rats were used for neurochemical studies. The results indicate that pretreatment with P...

objective: in the present work, the effects of different fractions of coriandrum sativum (c. sativum), on pentylenetetrazole (ptz)-induced seizures and brain tissues oxidative damage were investigated in rats. materials and methods: the rats were divided into the following groups: (1) vehicle, (2) ptz (90 mg/kg), (3) water fraction (wf) of c. sativum (25 and 100 mg/kg), (4) n-butanol fraction (...