in previous studies, mebudipine, a dihydropyridine calcium channel blocker, showed a considerable potential to be used in cardiovascular diseases. the aim of the current study was to develop a valid method using reversed-phase high performance liquid chromatography coupled with electrospray ionization mass spectrometry to assay mebudipine in the human plasma. separation was achieved on a zorbax...

Contamination of food producing animals by veterinary drug residues, particularly quinolones, is an essential issue in food safety that causes increasing concern in consumers. The aim of this study was to investigate the occurrence of enrofloxacin and its main metabolite, ciprofloxacin, in chicken tissue samples slaughtered in Tabriz, Iran. Totally 250 samples including liver, muscle, gizzard, ...

The manufacturing equipment in pharmaceutical industry, could be used in multiple and sharedproduction lines, therefore there is the possibility for the products components and active ingredients tointermix and pollute one another. In this purpose the cleaning methods are used, to reduce the residueslevels from the machinery surfaces and decrease the residues to acceptable level but these metho...

glichkeiten. Angewandte Chemie 105: 659; Angewandte Chemie, International Edition English 32: 629. Francuskiewicz F (1994) Polymer Fractionation (Springer Lab Manual). Heidelberg: Springer Verlag. GloK ckner G (1987) Polymer Characterization by Liquid Chromatography. Amsterdam: Elsevier. GloK ckner G (1991) Gradient HPLC of copolymers and chromatographic cross fractionation. Berlin: Springer Ve...

Chemical modification of target analytes is widely used in modern analytical methods. This review focuses on the application of chemical modification techniques is the simultaneous analysis of metallic species by capillary electrophoresis, liquid chromatography and gas chromatography. Emphasis is placed on the procedures relating to analyses carried out by capillary electrophoresis. The develop...

Triamterene, a diuretic drug used in combination with other drugs for the treatment of hypertension, was found in the blood and urine of a fatal aircraft accident victim. The extraction and identification of triamterene is difficult. It exhibits poor extraction efficiency using some standard base-extraction procedures, and the parent drug is unsuitable for analysis using gas chromatography. In ...

Drug counterfeiting has exaggerated dramatically over the past decade causing a significant threat to human health. It must be processed in regard to medicines and the matter isn't restricted to a violation of belongings rights, however clearly involves every kind of poor quality pharmaceutical merchandise, including falsified and substandard medicine. The present paper discuss the review of th...