Export Background. Recent trials in liver machine perfusion (MP) have revealed unique challenges beyond those seen most clinical studies. Correct trial design and interpretation of data are essential to avoid drawing conclusions that may compromise patient safety increase costs. Methods. The International Liver Transplantation Society, through the Special Interest Group “DCD, Preservation Machi...

Small-scale devices enable rapid development and optimization, while many exist for fed-batch cultures, there are few comparable high cell density perfusion cultures. To address this gap, pseudo-perfusion methodologies were developed in microwell plates at mL-scale capable of achieving the specific characteristics culture, including density, retention increased productivity. Pseudo-perfusion wa...

formula one legend michael schumacher hit his head severely while skiing on december 29, 2013. he was operated on for brain decompression and left in a coma fighting for life. in such severe brain injury with cerebral contusion and hemorrhage following head trauma, refractory to medical therapy and with increasing cerebral oedema and intracranial pressure, critically low cerebral perfusion can ...

Abstract Introduction Complement activation is a key mechanism of Ischaemia reperfusion injury, with the alternative pathway driving damage in particular. The main regulator factor H. We hypothesised that homodimeric mini-factor H (HDM-FH; PMID:29588430) may protect transplanted kidneys from complement mediated when administered during normothermic perfusion machine perfusion. Methods Kidneys w...

(1) Background: Arrhythmia, which is an umbrella term for various types of abnormal rhythms heartbeat, has a high prevalence in both the general population and patients with coronary artery disease. So far, it remains unclear how different arrhythmia would affect myocardial perfusion risk/severity ischemia. (2) Methods: A computational model circulation coupled to global cardiovascular system w...

Abstract
 Introduction: Pulmonary embolism is still a challenge in diagnosis due to its variable and nonspecific symptoms. Computed tomography ventilation/perfusion scanning are the modalities most commonly used of pulmonary embolism, both have their advantages disadvantages. One important factors assessment localization diagnostic accuracy these modalities, which serves model different st...

Background: This review article focused on the utilization and impact of current neuroimaging techniques for patient with acute stroke, emphasizing how imaging builds upon clinical assessment to establish diagnosis or etiology guide therapeutic decisions. When requesting examinations in patients stroke symptoms; it is crucial evaluate four significant parameters stroke; parenchyma, vessels, per...

BACKGROUND Chronic dysfunctional but viable myocardium may exhibit contractile reserve and/or intact perfusion. Segments with intact perfusion without contractile reserve are frequently observed inpatients with ischemic cardiomyopathy. The clinical relevance of this observation is unclear; in particular, the functional outcome after revascularization is unknown. Thus, contractile reserve (using...

UNLABELLED This study was designed to assess the prognostic value of stress myocardial perfusion SPECT with electrocardiographic (ECG) gating in patients undergoing noncardiac surgical treatment. METHODS The study included 481 consecutive patients who underwent noncardiac surgery and had been referred for preoperative myocardial perfusion scintigraphy. Myocardial scintigraphy used (99m)Tc-lab...