Chemotherapy is used for the treatment of rapidly growing cell diseases in body. It most different kinds tumors. can develop neuropathic pain due to damage peripheral nerve cells and it called Chemotherapy-Induced Peripheral Neuropathy (CIPN). In this study, we have reported protective effects 4-allyl pyrocatechol (4-APC) its derivatives from biochemical functional deficits associated with oxal...

Objective To systematically evaluate the diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy. Methods We searched EMBASE (OvidSP), MEDLINE (OvidSP), the Cochrane Library, and Web of Science to identify diagnostic accuracy trials of monofilament tests for detecting diabetic peripheral neuropathy. We used a hierarchical summary receiver operating characteristi...

In multiple myeloma, peripheral neuropathy has for a long time been considered as mainly secondary to the plasma cell dyscrasia itself. With the advent of new targeted drugs such as thalidomide and bortezomib, the iatrogenic neurotoxicity has become the leading cause of peripheral neuropathy. This review discusses the pathogenesis, incidence, risk factors, diagnosis, characteristics, and manage...

PURPOSE/OBJECTIVES To review the literature documenting the scope, treatment, and prevention of chemotherapy-induced neuropathy. DATA SOURCES Published abstracts, primary research literature, and textbook chapters. DATA SYNTHESIS Recent improvements in the management of other treatment-related toxicities have led to peripheral neuropathy becoming a dose-limiting toxicity of commonly used ch...

Michelle L. Mauermann, MD Ted M. Burns, MD Peripheral neuropathy is common, with an estimated prevalence of 2% in the general population and prevalence as high as 8% in those over the age of 55 years.1 Residents and fellows will undoubtedly evaluate many patients with various types of peripheral neuropathies during their careers. The evaluation for the etiology of a patient’s peripheral neuropa...

OBJECTIVE Heightened expression of the receptor for advanced glycation end products (RAGE) contributes to development of systemic diabetic complications, but its contribution to diabetic neuropathy is uncertain. We studied experimental diabetic neuropathy and its relationship with RAGE expression using streptozotocin-induced diabetic mice including a RAGE(-/-) cohort exposed to long-term diabet...

OBJECTIVE CNS or peripheral nervous system dysfunction sometimes occurs in Henoch-Schönlein patients. METHODS We review all Henoch-Schönlein cases published after 1969 with CNS dysfunction without severe hypertension and neuroimaging studies (n = 35), cranial or peripheral neuropathy (n = 15), both CNS and peripheral nervous system dysfunction without severe hypertension (n = 2) or nervous sy...

OBJECTIVE To illustrate the prevalence of different types of neuropathy in diabetic patients with diabetic foot. METHODS This is a retrospective study of 229 diabetic foot patients treated at Princess Haya Hospital Hyperbaric Department, Aqaba, Jordan from January 1997 to January 2008, who were found to have different types of neuropathy. Neuropathy diagnosis was reached through investigating...