Impact of metal in vitro administration on rat tissue oxygen consumption is referred in the first part. Toxicological implications of in vivo metal administration to rats and the study of potential penetration of metal into the rat brain, which may eventually result in oxygen radical production are presented in second part.

TOR (target of rapamycin) signaling regulates life span in many organisms, but the mechanism behind the effect is unknown. In this issue of Cell Metabolism, Pan and colleagues (2011) find that reduced TORC1 activity promotes yeast life span via a mechanism that, paradoxically, relies upon the production of normally deleterious reactive oxygen species.

A comprehensive understanding of ROS (reactive oxygen species)-dependent cellular interaction requires the previously unmet ability to simultaneously monitor the intra- and extra-cellular environments. The present review assesses the potential of novel electrochemical and fluorescent-based nanosensor approaches to address the limitations of existing techniques for ROS analysis. Data generated b...

The fluorescence intensity and lifetime of the 4,4'-difluoro-4-bora-5-(p-oxoalkyl)phenyl-3a,4a-diaza-s-indacene (1) show a strong correlation with the viscosity of the medium due to the viscosity-dependent twisting of the 5-phenyl group, which gives access to the dark nonemissive excited state. We propose a sensitive and versatile method for measuring the local microviscosity in biological syst...

SUN, XIAOCUN AND MICHAEL B. ZEMEL. 1 ,25Dihydroxyvitamin D3 modulation of adipocyte reactive oxygen species production. Obesity. 2007;15:1944–1953. Objective: We have previously shown 1 ,25-dihydroxyvitamin D3 [1 ,25-(OH)2D3] to inhibit mitochondrial uncoupling protein 2 (UCP2) expression in adipocytes and that in vivo suppression of calcitriol levels with calcium-rich diets increases UCP2 expr...

A RANDOMIZED CLINICAL TRIAL by the Acute Respiratory Distress Syndrome Network (1) demonstrated a 22% reduction in mortality in patients by reducing the tidal volume for mechanical ventilation from the conventional setting of 12 ml/kg to a lower setting of 6 ml/kg. This dramatic decrease in mortality has stimulated significant interest in the mechanisms of ventilatorinduced lung injury and the ...

Copyright © 2009 American Heart Association. All rights reserved. Print ISSN: 0194-911X. Online 72514 Hypertension is published by the American Heart Association. 7272 Greenville Avenue, Dallas, TX DOI: 10.1161/HYPERTENSIONAHA.109.130054 2009;53;885-892; originally published online Apr 27, 2009; Hypertension Francesco Addabbo, Monica Montagnani and Michael S. Goligorsky Mitochondria and Reactiv...

The zooplankton community structure in Eğirdir Lake (Isparta-Turkey) was studied monthly throughout an annual cycle (January 2010-December 2010). The zooplankton community was represented by three main groups: Rotifera, Cladocera and Copepoda, respectively comprised 89.62%, 7.78% and 2.60% of the total zooplankton abundance. Eğirdir Lake was dominated by the rotifera Polyarthra dolichoptera in ...