Plasma concentration-time curves of pethidine and norpethidine were studied in 25 children allocated after operation to three groups to receive pethidine 1 mg kg-1 i.v., i.m. or rectally. Peak concentrations occurred after 5 +/- 1, 10 +/- 2, and 60 +/- 10 min, respectively, while the maximum concentrations amounted to 2800 +/- 462, 1609 +/- 367 and 531 +/- 179 nmol litre-1, respectively. The ar...

Sir,—May I offer some comments on the article by Drury and Gilbertson? (Brir. J. Anaesth. (1970), 42, 1021). (1) A likely cause of the hyperpyrexia is the combination of pediidine and atropine in conjunction with anaesthesia. Pediidine potentiates atropine and probably atropine potentiates pethidine. Pethidine is not needed for premedication, and probably can be dispensed with safely. (2) It is...

Saddle blockade with pethidine hydrochloride was performed in 111 patients undergoing short surgical operations on the perineum. A dose of 5% pethidine 0.5 mg kg-1 was injected to the subarachnoid space at L4-5 or L5-S1 with the patient in the sitting position. Sensory blockade was achieved in 5.28 +/- 1.43 min. This extended to the sacrococcygeal area, perineum, buttocks and posterior surface ...

A variety of chemical methods are available to increase the analgesic activity of pethidine (I). Replacement of the carbethoxy group (COOC2H,) by propionoxy (OCOC,H,) is one of the known methods.2-6~*~11-13~ 16* 101 201 23-26 Another one is the replacement of N-CH, by selected N-substituents such as aralkyl,2*43 6, 179 18, 2 2 propiophen~ne,~~ lo large alkyl groups,2l morpholinoethy1,lt 73 l4 a...

background and purpose: suitable sedation during gastrointestinal (gi) tract endoscopy leads to the patient’s and the physician’s satisfaction and enhances the quality and the adequacy of the procedure. materials and methods: in a clinical trial, 140 patients were randomly assigned into two groups in order to compare the adequacy of upper gi tract endoscopy after choosing the type of sedation b...

it has been sugeested since long that peripheral nerves possess opiod receptors and this has tempted clinicans in adding narcotics to local anesthetics to prolong the analgesic effects of these solutions. in this regard, we studied 45 patients undergoing surgical procedures on upper extremities. the patients scheduled for surgery were divided in to three groups, each comprising of 15 patients a...