AIM To compare the efficacy of ketoprofen and pethidine for peri-operative analgesia and post-operative nausea and vomiting in children undergoing vitreoretinal surgery and surgery for retinal detachment. MATERIAL AND METHODS Children aged 7 to 16 years and ASA I status, undergoing vitreo-retinal surgery were randomly allocated to receive either ketoprofen 2mg/kg or pethidine 1mg/kg intraveno...

OBJECTIVE To study early hemodynamic changes and duration of postoperative analgesia between two study groups of intrathecal pethidine and bupivacaine heavy in patients undergoing caesarean section. METHODOLOGY Total number of 60 patients of ASA I and II, undergoing caesarean section were enrolled in the study. All the patients were divided into two groups: Pethidine and Bupivacaine heavy. Th...

OBJECTIVE To evaluate the effect of gabapentin on the incidence and severity of postoperative nausea and vomiting (PONV) after open cholecystectomy. SUBJECTS AND METHODS A total of 90 patients scheduled for elective open cholecystectomy were randomly assigned to either a gabapentin group (600 mg, 2 h before surgery) or a placebo group. For the analysis, 1 patient was excluded from the gabapen...

Introduction: Pethidine is commonly used to treat shivering after general anesthesia (GA), yet respiratory depression may subsequently occur. Warming methods such as warm fluids and/or humid-warm oxygen inhalation can reduce shivering after GA. This randomized clinical trial aimed to compare the effects of three different methods on the reduction of shivering and their hemodynamic and respirato...

BACKGROUND Intramuscular pethidine is routinely used throughout the UK for labour analgesia. Studies have suggested that pethidine provides little pain relief in labour and has a number of side effects affecting mother and neonate. It can cause nausea, vomiting and dysphoria in mothers and can cause reduced fetal heart rate variability and accelerations. Neonatal effects include respiratory dep...

BACKGROUND The use of pain-relieving drugs during labor is now part of standard care in many countries throughout the world. Each method of pain relief has its own risks and benefits, variations in effectiveness, and availability and acceptability. OBJECTIVES This study aimed to assess the efficacy and safety of intramuscular pethidine as an analgesic during labor by comparing it to inhaled 5...

A review of the current literature shows pethidine (meperidine) use to be less favourable than commonly thought. When first synthesised in the 1930s, it was prematurely lauded as a substitute for morphine, and marketed as a drug lacking many of the adverse effects such as respiratory depression, urinary retention, constipation and chemical dependency typical of opioids such as morphine. None of...

objective: renal colic is a common cause of emergency room visits. due to the spontaneous passage of more than 90% of kidney stones, treatment in the emergency department (ed) is limited to pain control. analgesics currently used are selected based on physician experiences and various theories from different sources. the aim of this study was to compare the common drugs (pethidine and diclofena...

In a double-blind investigation of the efficacy on pain following abdominal or orthopaedic surgery, meptazinol 100 mg, a new hexahydroazepine derivative, was found to be equipotent with pentazocine 60 mg and pethidine 100 mg when given i.m. Analgesia was maximal 30-60 min after injection and was still present at the end of 2 h. The duration of action of meptazinol was estimated to be 4 h. Mepta...