PURPOSE Nanoparticles based on stimuli-sensitive drug delivery have been extensively investigated for tumor targeting. Among them, pH-responsive drug targeting using pH-sensitive polymers has attracted attention because solid tumors have an acidic environment. A dextran-b-poly(L-histidine) (DexPHS) copolymer was synthesized and pH-responsive nanoparticles were fabricated for drug targeting. M...

Front Cover: Polypiperazines are hydrophilic pH-sensitive polymers reaching high transfection efficiency and guaranteeing good biocompatibility. They almost charge-neutral under physiological conditions avoiding unintended side effects, while the isopropyl-modified polypiperazine outperforms commercial linear PEI at low N/P ratios. qPCR revealed that pDNA can still be amplified complexed with p...

Formation of non bonded organic layer around inorganic particles like iron sulfide and zeolites, was hypothesized as starting point for one of the possible mechanisms of the origin of life on earth. In this study, the general circumstances needed for creation of such organic layer was investigated. An aliphatic hydrocarbon (hexane), an aromatic hydrocarbon (toluene), an alcohol (n-octanol) and ...

The study was designed to investigate the impact of colonic pH changes on formulated colon targeted Mesalamine matrix tablets in the treatment of inflammatory bowel disease (IBD). Mesalamine tablets were fabricated with guar gum as Polymer system. The different batches of Mesalamine tablets (GMM1GMM6) were compressed with increasing proportion of guar gum and HPMC E15 LV. The different buffer c...

Hydrogels are the 3 dimensional cross linked polymeric networks which absorb the water 10-20 times of its molecular weight. Hydrogels are sensitive to different environmental stimuli like pH, temperature, ion, electric signals, light, pressure, antigen specific, enzyme sensitive, and glucose levels. When the environment is get change they get swell, and swelling is the most important characteri...

Stimuli−responsive polymers respond with large property changes to small physical or chemical stimuli. These functional polymers are known as “smart”, “intelligent”, “stimuli−responsive”, or “environmentally sensitive” polymers. They can take many forms: they may be dissolved in aqueous solution, adsorbed or grafted on aqueous−solid interfaces, or cross−linked in the form of hydrogels. Many dif...

The rapid advancement of biomedical research has led to many creative applications for biocompatible polymers. As modern medicine discerns more mechanisms, both of physiology and of pathophysiology, the approach to healing is to mimic, or if possible, to recreate the physiology of healthy functioning. Thus, the area of smart polymers for responsive drug delivery has evolved. The developments fa...

Interest in stimuli-responsive polymers is steadily gaining increasing momentum especially in the fields of controlled and self-regulated drug delivery. Delivery systems based on these polymers are developed to closely resemble the normal physiological process of the diseased state ensuring optimum drug release according to the physiological need. Also termed 'environmental-sensitive' or 'smart...

Purpose: To study the release behaviour of ciprofloxacin hydrochloride tablet matrices prepared with different polymers in dissolution media pH. Methods: Different formulations slow-release matrix tablets were polymers, namely, ethyl cellulose (Etc), hydroxyethyl (Hec), hydroxypropyl methylcellulose (Hpc), and Eudragit® L-100 (Eud) using embedding technique. The characterized studies their prof...