Medicating drinking water with tetracycline is commonly used in swine production systems to treat and prevent disease outbreaks. However, little information is known of the pharmacokinetics of this medication in water formulations. Twenty-four barrows, divided into 1 control group (of nontreated animals) and 3 equally sized treatments groups (n = 6/group), were treated with tetracycline water m...

BACKGROUND & AIMS Prophylactic injections of factor VIII reduce the incidence of bleeds and slow the development of joint damage in people with hemophilia. The aim of this study was to identify optimal person-specific prophylaxis regimens for children with hemophilia A. METHODS Analytic and numerical methods were used to identify prophylaxis regimens which maximize the time for which plasma f...

The objective was to evaluate possible pharmacokinetic and pharmacodynamic interactions for repeated nightly zolpidem dosing with fluoxetine. Twenty-nine healthy female volunteers (mean age, 25. 6 years) received zolpidem (10 mg) and fluoxetine (20 mg) in the following open design: zolpidem on night 1 followed by 1 washout day, a daily morning dose of fluoxetine on days 3 through 27, and a morn...

Journal of the Malta College of Pharmacy Practice 23 In this paper an overview will be given of how knowledge of pharmacokinetic mechanisms determines which pharmacokinetic characteristics an AED should have. Various clinical factors such as age, underlying physiological conditions and drug interactions will also affect the pharmacokinetics and efficacy of AED medication. It will be shown how b...

BACKGROUND A recent drug interaction study reported that when azithromycin was administered with the combination of ivermectin and albendazole, there were modest increases in ivermectin pharmacokinetic parameters. Data from this study were reanalyzed to further explore this observation. A compartmental model was developed and 1,000 interaction studies were simulated to explore extreme high iver...

In the present research article, we applied Wilks Lambda on two different pharmacokinetic studies. In the first study we check the bioavailability of the three different formulations (Dynapar QPS). We check the effectiveness of these formulations using Wilks Lambda. We found no significant difference in the effectiveness as measured by pharmacokinetic parameters. For the second study, we test t...

INTRODUCTION Due to high inter-individual variability in peripheral pharmacokinetic parameters, dosing of antipsychotics currently relies on clinical trial-and-error, and predicting antipsychotic plasma concentrations before changing a dose has been a challenge. METHODS Patients with schizophrenia receiving a stable dose of olanzapine were included. 2 plasma samples were collected at 2 given ...

Proton pump inhibitors (PPIs) have become known for both their therapeutic effect and good safety profile. An application was submitted to the US Food and Drug Administration for approval of a reformulated PPI product that failed bioequivalence testing, but was submitted on the basis of the long history of PPI use as a "surrogate" for equivalence. This review evaluates the safety data for PPIs,...

The pharmacokinetic interaction between lansoprazole with phenytoin and ciprofloxacin in healthy male volunteers was evaluated. In two separate experiments, a single dose of 30 mg lansoprazole was administered alone or in combination with phenytoin or ciprofloxacin to 11, respectively 18 healthy volunteers in two stages treatment of study design, separated by a period in which the phenytoin or ...

Twelve healthy volunteers were enrolled in an open-label, randomized, crossover study. Subjects received single doses of theophylline (5 mg/kg) with and without multiple-dose terbinafine, and 11 blood samples were collected over 24 h. The study phases were separated by a 4-week washout period. Theophylline serum data were modeled via noncompartmental analysis. When the control phase (i.e., no t...