the objective of this study was to evaluate kinetics and the residual decline of tylosin in milk and plasma of lactating najdi ewes following single intramuscular injection of tylosin at the dose of 10 mg/kg. blood and milk samples were collected from the ewes before and at different time intervals after treatment. tylosin concentrations were determined by microbiological agar plate assay using...

meropenem, a carbapenem antibiotic, has a broad-spectrum activity and is active against staphylococcus aureus, streptococcus pneumoniae, haemophilus influencae, moraxella catarrhalis, gram-negative enteric bacilli as escherichia coli, klebsiella, enterobacter, serratia and pseudomonas aeruginosa. meropenem has excellent penetration in body tissues and in cerebrospinal fluid (in the presence of ...

amikacin is a bactericidal aminoglycoside. aminoglycosides inhibit bacterial protein synthesis. the antibacterial spectrum of amikacin is the broadest of aminoglycosides. because of its resistance to many of the aminoglycosides-inactivating enzymes, it has a special role in hospitals where gentamicin- and tobramycin-resistant microorganisms are prevalent. amikacin is active against the majority...

the objective of the present study was to evaluate the pharmacokinetic parameters and bioavailability of a selective histamine (h1)-receptor antagonist, cetirizine hydrochloride (ctz), following administration of a single oral dose of the drug. the properties of a test compound were compared with those of a reference product in a randomized cross-over study in 12 volunteers. blood samples were ...

a sensitive, accurate and rapid reverse phase hplc method was described to quantitate levels of acyclovir in human plasma. the drug, internal standard (metronidazole) and phosphate buffer (0.05 m) were added to serum samples and vortexed for 30 sec. a mixture of isopropyl alcohol:dichloromethane (60:40) was then added and vortexed for 3 min. samples were centrifuged and the supernatant layer wa...

background: imatinib is known as the drug of choice for treatment of chronic myeloid leukemia (cml). for adults the recommended daily dosage of 400 mg requires simultaneous intake of up to four capsules or tablets each 100 mg. a new 400 mg film coated tablet developed due to the need to swallow multiple capsules or tablets per dose and that was a negative impact on treatment adherence. subjects...

gentamicin is a bactericidal aminoglycoside antibiotic, it inhibits the protein synthesis. gentamicin is active against the majority of aerobic gram-negative bacilli such as pseudomonas, klebsiella and escherichia coli. the gentamicin doses are 3 mg/kg once-daily for preterm newborns < 35 weeks of gestation and 4 mg/kg once-daily for newborns > 35 weeks of gestation. the monitoring of gentamici...

the new-aeds, whose developments were motivated following the discovery of the valproate and its marketing in the u.s in 1978, have presented more therapeutic options. there are approximately twenty four fda-approved antiepileptic drugs for use in patients with epilepsy, five of which were identified and have come on to the market between 2009 and 2012. the new-aeds are of interest, not due to ...

Colistin relates to the polymyxin group of antibiotics. This antibiotic is still used to destroy gram-negative bacteria as a last resort. However, resistance to this antibiotic has been reported and is appearing day by day. Not much information is available on the exact mechanisms of resistance to this antibiotic. Also, not enough information about pharmacokinetics and pharmacodynamics is avail...

intoduction: therapeutic radiopharmaceuticals are radiolabeled molecules to deliver sufficient doses of ionizing radiation to specific disease sites such as bone metastases, brain and liver tumors and bone marrows malignancies including multiple myeloma. among some therapeutic radiopharmaceuticals, 166ho-1,4,7,10 -tetraazacyclo dodecane-1,4,7,10 tetraethylene phosphonic acid (166ho-dotmp) is us...