pharmacokinetic/pharmacodynamic (pk/pd) relationships describe the quantitative relationships between the drug-induced effects and the concurrent corresponding drug concentrations in an individual. since a long time, rough qualitative relationships have been described between neurological presentation and plasma ethanol concentration in acute ethanol ingestion. however, to date, precise quantit...

voriconazole is an antifungal triazole, approved for management of invasive fungal diseases in patients. it is absorbed during two hours and its serum levels will be above 90%, based on the underlying factors, when the drug is administered orally. voriconazole shows a propotional increase in an area under the plasma concentration-time curve (auc), with increasing dose. plasma protein binding of...

Eslicarbazepine acetate is an advanced antiseizure medication that improvement upon carbamazepine and oxcarbazepine. This novel regulates voltage-gated sodium channels provides fewer adverse effects better tolerability. Herein, we present the characteristics, pharmacokinetics, drug interactions of eslicarbazepine based on research has been conducted to date. Key words: acetate; Pharmacokinetics...

This paper addresses the beginning of toxicokinetics in Spain by group Prof. Bartolomé Ribas 60s last century, as well interdisciplinary collaboration that occurs between academics Royal National Academy Pharmacy (RANF) and more specifically with Rafael Cadórniga, who was a pioneer Biopharmacy Pharmacokinetics studies Spain. scientific is magnificent example work strong interrelationship pharma...

a quantitative analysis method for fudosteine in human serum by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (hplc-esi/ms/ms) was established, which shows high sensitivity and selectivity. the mobile phase composition was 75% 20 mm acetic acid and 25% acetonitril, which was pumped at a flow rate of 0.40 ml/min. the overall chromatographic run time was ...

the pharmacokinetics of levofloxacin following its single intramuscular administration (3 mg/kg) was investigated in six male buffalo calves. peak plasma level of 2.95 ± 0.13μg/ml was observed at 1 h and the drug level above mic90  in plasma was detected up to 12 h of administration. the bioavailability was 68.1 ± 5.4% and levofloxacin was bound to the plasma proteins to the extent of 19.1 ± 1....

a validated hplc method was developed to determine doxorubicin concentration in a small volume of rat plasma (60 µl) with convenient fluorescence detection. sample preparation includes a simple one-step liquid-liquid extraction using minimum amount of organic solvent, with extraction recoveries more than 95%. the analysis was accomplished using perfectsil c18 column maintained at 35 °c and a mo...

Pharmacokinetics, Dynamics & Metabolism, Pfizer, La Jolla, California (E.K.), Preclinical and Translational Pharmacokinetics and Pharmacodynamics, Genentech, South San Francisco, California (A.V.K.), Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, Novartis Pharma, Basel, Switzerland (M.W.), Drug Metabolism, Pharmacokinetics & Bioanalysis Department, AbbVie, Wo...