Failure of response to treatment or recurrent disease is often noted in patients with penile intraepithelial neoplasia. Photodynamic therapy has recently been added to the list of treatment modalities used for this diagnosis. Our primary objective was to study the results of photodynamic therapy in the treatment of penile intraepithelial neoplasia in men over the age of 40 years. Ten patients a...

Photodynamic therapy (PDT) kills cancer cells by converting tumour oxygen into reactive singlet oxygen ((1)O2) using a photosensitizer. However, pre-existing hypoxia in tumours and oxygen consumption during PDT can result in an inadequate oxygen supply, which in turn hampers photodynamic efficacy. Here to overcome this problem, we create oxygen self-enriching photodynamic therapy (Oxy-PDT) by l...

Interannual-to-decadal variability of North Atlantic air-sea CO2 fluxes S. Raynaud, O. Aumont, K. B. Rodgers, P. Yiou, and J. C. Orr Laboratoire des Sciences du Climat et de l’Environnement, CEA, Gif-sur-Yvette, France Laboratoire d’Océanographie Dynamique et de Climatologie, Paris, France Received: 11 July 2005 – Accepted: 8 August 2005 – Published: 30 August 2005 Correspondence to: S. Raynaud...

Nontoxic prodrugs, especially activated by tumor microenvironment, are urgently required for reducing the side effects of cancer therapy. And combination of chemo-photodynamic therapy prodrugs show effectively synergetic therapeutic efficiency, however, this goal has not been achieved in a single molecule. In this work, we developed a mitochondrial-targeted prodrug PNPS for near infrared (NIR) ...

Photodynamic therapy (PDT) is a light based therapy used to ablate tumors. As practiced in oncology a photosensitizing agent is applied and then activated by a specific wavelength and energy of light. This light energy in the presence of oxygen will lead to the creation of the photodynamic reaction which is cyto and vasculo toxic. This paper will review the mechanisms of action of PDT and how t...

Recently, the Treatment of Age-Related Macular Degeneration with Photodynamic Therapy (TAP) Study Group reported that photodynamic therapy with verteporfin (Visudyne; Ciba Vision, Bülach, Switzerland) can reduce the risk of vision loss in patients with subfoveal choroidal neovascularization (CNV) due to age-related macular degeneration (AMD). This is a review of the circumstances leading to the...

STATEMENT OF THE PROBLEM The presence of bacterial biofilms is the major cause of gingivitis and periodontitis, their mechanical removal is not often enough. Therefore, laser therapy and photodynamic therapy can be effective as adjunctive treatment. PURPOSE This study aimed to evaluate the impact of these treatments on the level of gingival crevicular fluid (GCF), inflammatory mediators, and ...

Citation: Karakullukcu B, Kanick SC, Aans JB, Sterenborg HJCM, Tan IB, Amelink A and Robinson DJ (2015) Integration of fluorescence differential path-length spectroscopy to photodynamic therapy of the head and neck tumors is useful in monitoring clinical outcome. Front. Phys. 3:20. doi: 10.3389/fphy.2015.00020 Integration of fluorescence differential path-length spectroscopy to photodynamic the...

Photodynamic therapy (PDT) is a minimally-invasive surgical tool successfully targeting premalignant and malignant disorders in the head and neck, gastrointestinal tract, lungs and skin with greatly reduced morbidity and disfigurement. The technique is simple, can commonly be carried out in outpatient clinics, and is highly acceptable to patients. The role of photodynamic therapy in the managem...