patients with alzheimer's disease have cognitive deficits, impaired long-term potentiation and learning and memory. a progressive reduction in cholinergic neurons in some areas of the brain such as cortex and hippocampus is related to the deficits in memory and cognitive function in alzheimer’s disease (ad). in the current project a new series of phthalimide derivatives were synthesized. p...

An efficient N-heterocyclic carbene (NHC) catalyzed sulfenylation reaction of α,β-unsaturated aldehydes with N-(arylthio)phthalimide has been developed. A wide variety of α-thioenals can be obtained with good to excellent yields and excellent Z-configuration.

OBJECTIVE(S) Alzheimer's disease (AD) is a neurodegenerative disorder in elderly patients. Decrease in cholinergic neurotransmission is the main known cause in the pathophysiology of the disease. Improvement and potentiation of the cholinergic system could be beneficial for treatment of the AD. Acetylcholinesterase inhibitors such as donepezil can enhance the duration of action of acetylcholine...

Self-aggregating calix[4]arenes carrying four DOTA ligands on the upper rim for stable complexation of paramagnetic GdIII-ions have already been proposed as MRI probes. In this work, we investigate the luminescence properties of TbIII-DOTA-calix[4]arene-4OPr containing four propyl-groups and compare them with those of the analog substituted with a phthalimide chromophore (TbIII-DOTA-calix[4]are...

The mol-ecule of the title compound [systematic name: 2-(4-tert-butyl-benz-yl)isoindoline-1,3-dione], C(19)H(19)NO(2), is V-shaped with a dihedral angle of 74.15 (7)° between the mean planes of the phthalimide unit and the benzene ring. The methyl groups of the tert-butyl substituent are disordered over two sets of positions, with an occupancy ratio of 0.700 (4):0.300 (4). In the crystal, inter...

As a result of the direct synthesis through oxidative dissolution of metallic copper powder in the presence of phthalimide and sodium hydride a new polymeric bimetallic coordination compound [Cu(phthal)4Na2(PrOH)2H2O]n was synthesized and characterized by a single crystal X-ray crystallography and IR spectroscopy. The copper(II) ions have a distorted tetrahedral environment (CuN4), while the co...

objective(s): alzheimer’s disease (ad) as progressive cognitive decline and the most common form of dementia is due to degeneration of the cholinergic neurons in the brain. therefore, administration of the acetylcholinesterase (ache) inhibitors such as donepezil is the first choice for treatment of the ad. in the present study, we focused on the synthesis and anti-cholinesterase evaluation of n...

There is considerable current interest in developing methods to integrate nanoparticles into optical, electronic, and biological systems due to their unique size-dependent properties and controllable shape. We report herein a versatile new approach for covalent immobilization of nanoparticles onto substrates modified with photoactive, phthalimide-functional, self-assembled monolayers. Upon illu...

The title mol-ecule, C(11)H(11)NO(3), lies on a crystallographic mirror plane which bis-ects the plane of the phthalimide unit and contains the C and O atoms of the 2-methoxy-ethyl group.

In the title compound, C(14)H(6)F(3)NO(2), the benzene ring and the phthalimide ring system make a dihedral angle of 60.12 (7)°. Weak inter-molecular C-H⋯O and C-H⋯F hydrogen bonds are present in the crystal structure.